ID W5L5X3_ASTMX Unreviewed; 714 AA.
AC W5L5X3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=RUN and TBC1 domain-containing protein 3 {ECO:0000256|ARBA:ARBA00030864};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000015235.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000015235.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the small G protein signaling modulator family.
CC {ECO:0000256|ARBA:ARBA00006296}.
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DR AlphaFoldDB; W5L5X3; -.
DR Ensembl; ENSAMXT00000015235.2; ENSAMXP00000015235.2; ENSAMXG00000014779.2.
DR eggNOG; KOG2222; Eukaryota.
DR GeneTree; ENSGT00940000157282; -.
DR HOGENOM; CLU_020721_0_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000014779; Expressed in brain and 14 other cell types or tissues.
DR CDD; cd11813; SH3_SGSM3; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR035833; SGSM3_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR PANTHER; PTHR47219:SF19; RUN AND TBC1 DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR Pfam; PF02759; RUN; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 115..306
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT DOMAIN 484..543
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 559..714
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
SQ SEQUENCE 714 AA; 81288 MW; 0AE736C11C32B1E6 CRC64;
MSGSYTPAPG GPFSALTPSM WPQDILAKYH QKDQNMDSEP QYDEFGFRID SEDGVEPREW
LRGDGAPQTE DPQQRLRWQA HLEFTHNHTV GDLTWDKISP SLPRSERLRS LVLGGIPHSM
RPQLWMRLSG ALQKKRTSEI SYREIIKNSS NDDTTAAKQI EKDLLRTMPT NACFSTLTSV
GVPRLKRVLR GLAWLYPDIG YCQGTGMVVS CLLLFLEEED ALWMMCALIE DLLPPSYFSS
TLLGVQTDQR VLRQLIVQYL PSLDQLLQEH DIELSLISLH WFLTSFASVV DIRILLRIWD
LLFYDGSIVL FQVTLGMLKI KEEELVSSEN SASIFNTLSD LPSQLEDGAA VLGEAVRLAG
SLSQDTLDSH RRKHLAYILA EQAQLNSNNS HTLNTNLNKV VRRQSLRRKS TLSSLLFGED
EAEALKAKNI KQTELVAALR EAITRTAEHF HCLDPRHCSM DLTPDYSMES HQRDHENFLV
VSRNRRRRAK ALLDFERHDD DELGFRKNDI ITIVSQKDEH CWVGELNGLR GWFPAKFVEV
LDERSKEYSL AGDDSVTEAI TDLVRGTLCP ALKAIFQHGL KKPSILGGPC HPWLFIEEAA
SREVERDFNS VYSRLVLCKT YRLDEDGKVL TPEELLYRAV QSVNMSHDSA HVQMDVKFRS
LICVGLKVLS KFAFSLSQDC ELPAKKEEKE QRPLKEGVQD MLVKHHLFSW DIDG
//
