ID W5L6Q9_ASTMX Unreviewed; 645 AA.
AC W5L6Q9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=ATP-binding cassette sub-family G member 2-like {ECO:0000313|Ensembl:ENSAMXP00000015521.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000015521.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000015521.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC Eye pigment precursor importer (TC 3.A.1.204) subfamily.
CC {ECO:0000256|ARBA:ARBA00005814}.
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DR AlphaFoldDB; W5L6Q9; -.
DR STRING; 7994.ENSAMXP00000015521; -.
DR Ensembl; ENSAMXT00000015521.2; ENSAMXP00000015521.2; ENSAMXG00000015075.2.
DR eggNOG; KOG0061; Eukaryota.
DR GeneTree; ENSGT00940000165949; -.
DR HOGENOM; CLU_000604_57_8_1; -.
DR InParanoid; W5L6Q9; -.
DR OrthoDB; 936137at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000015075; Expressed in embryo and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR48041; ABC TRANSPORTER G FAMILY MEMBER 28; 1.
DR PANTHER; PTHR48041:SF49; ATP-BINDING CASSETTE, SUB-FAMILY G (WHITE), MEMBER 2B-RELATED; 1.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 427..449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 539..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 621..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..287
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 645 AA; 71754 MW; EF59A736FB9D311F CRC64;
MSMEAGAETG GETGGECEAS VDSESAALCS QNPGPCVSFY NVRYCVKERA GLFSFKWVEK
EILKDVSGIM NSGMNAIMGP TGSGKTSLLD VIAGRKDPRG LKSGKVLVDN ALVTSSLRLS
CAYVVQNDVL MGTLTVRENL AFSANLRLSL AEYSSSDKAM KVESVIKELG LTDCANTKIG
TEFLRGVSGG ERKRCSIGME LITSPSLLFL DEPTTGLDSN TANAIIDLLH RLSRSGKTII
FSIHQPRYSI YRQFDHLTLM NKGEIIYAGS ADKALTYFEE IGYKCEPFNN PADFFLDITN
EAFSLQANSS NSDKAEDING CELMLVSENA LAVKYRQSPQ CCSVIQQLQE LTEGIKPEDK
PDSDQASYPT TFCYQLMLVS TRTVKNILRN PQTSYAQLFL NIFFGILVGL IYYQIPHTLP
EALQNRTGAF FFLTINMVFG NLSAVELFIS ERVLFIHETS SGYYRTSAYF LSKVFADLLP
NRILPVFVFS AIPYFMMALK PEVEAFFLYC VTMSMISLSA VSLAFLVSAS VGSFAMANIL
IALPFVFMMV FGGFLVNLNS MLSWMSWLKW ISIFRYGFNA LAINELKGQE FTSNYTRMTG
EMYLDNQEID YSTWGFWQNQ VALMGIMCVC LLLAYVQLRR ISRLK
//