ID W5L6X0_ASTMX Unreviewed; 796 AA.
AC W5L6X0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000015582.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000015582.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR AlphaFoldDB; W5L6X0; -.
DR STRING; 7994.ENSAMXP00000015582; -.
DR Ensembl; ENSAMXT00000015582.2; ENSAMXP00000015582.2; ENSAMXG00000015136.2.
DR eggNOG; KOG1226; Eukaryota.
DR GeneTree; ENSGT01090000259987; -.
DR HOGENOM; CLU_011772_0_0_1; -.
DR InParanoid; W5L6X0; -.
DR OrthoDB; 5475862at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000015136; Expressed in pharyngeal gill and 12 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 4.10.1240.30; -; 1.
DR Gene3D; 1.20.5.100; Cytochrome c1, transmembrane anchor, C-terminal; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR040622; I-EGF_1.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF25; INTEGRIN BETA-3; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF18372; I-EGF_1; 1.
DR Pfam; PF08725; Integrin_b_cyt; 1.
DR Pfam; PF07965; Integrin_B_tail; 1.
DR Pfam; PF00362; Integrin_beta; 1.
DR PIRSF; PIRSF002512; Integrin_B; 1.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM01241; Integrin_b_cyt; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00243; INTEGRIN_BETA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..796
FT /note="Integrin beta"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017185079"
FT TRANSMEM 726..748
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..469
FT /note="Integrin beta subunit VWA"
FT /evidence="ECO:0000259|SMART:SM00187"
FT DOMAIN 641..725
FT /note="Integrin beta subunit tail"
FT /evidence="ECO:0000259|SMART:SM01242"
FT DOMAIN 749..795
FT /note="Integrin beta subunit cytoplasmic"
FT /evidence="ECO:0000259|SMART:SM01241"
FT DISULFID 36..469
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 44..54
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 47..83
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 57..72
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 211..218
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 266..307
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 408..420
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 440..688
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 467..471
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 482..493
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 490..528
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 495..504
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 534..539
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 536..569
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 541..554
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 556..561
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 575..580
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 577..608
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 582..591
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 593..600
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 614..619
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 616..664
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 621..631
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 634..637
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 641..650
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 647..720
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 668..696
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
SQ SEQUENCE 796 AA; 87063 MW; 85699BE3C82B6B28 CRC64;
MTSGQHFSEM GTLLLHVWTV LLVLIPVSTG SGTNICTSRG VRTCQECLSI HPSCAWCSQP
DDGQGRSSIA RCNLENLLKG DGCRKEFIVS PVSKLTVGEN RPLSDKAQGS SSDVTQIQPQ
RIHLTLRPGD SKTFTVTVRQ VADYPVDLYY LMDLSYSMND DLASLRSLGS DLATAMGKTT
SNLRMGFGAF VDKTVYPYMY MFPPEIVSNP CVSMNTVCRP QFGYKNVLSL TEQVDRFTEE
VKKQVVSRNR DSPEGGFDAV LQAVVCKDKI GWRSDASHLL VFTTDATTHS ALDGRIAGIV
QPSDGGCYVN QDNDYEKSTV LDYPSVAMLA DKLSENNINL IFAVTDNVMP LYLNYSKLIP
GTTVGKLYRD SKNVIQLILD AYANIRSKAE LEVLNVPDEL ILSFNATCLN GEVVTGVRSC
SGLKIGDTVS FSVEAKLSGC PKERNRTFII KPLGLKDTLQ VTVDFTCNCD CQDSAEPASP
ACSNNGTLEC GVCLCDAGRL GSHCECTEGD YKPTEADSCS TGPQGPICSG RGDCVCGQCQ
CHSSNFGKVW GKQCECDDFN CVRFKGQICS GHGDCMCGFC QCNPDWSGEN CNCSRRTDSC
MSSIGLMCSG RGQCVCGACE CTQPGAYGAT CEKCPTCPDS CTIKKDCVEC KHYKRGPLFE
KKSCNTICRD EITLVDELVF QEKSAVNCTY KDEDDCVHHF QYYEDISGKS ILYLVKEPEC
PKGPDILVVV AYVAGSILLL GLAGLLIWKL LITIHDRREF AKFEEERAKA KWEAANNPLY
RGATTTFTNV TYRGNS
//
