ID W5L718_ASTMX Unreviewed; 815 AA.
AC W5L718;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=G protein-coupled receptor 155 {ECO:0000313|Ensembl:ENSAMXP00000015630.2};
GN Name=GPR155 {ECO:0000313|Ensembl:ENSAMXP00000015630.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000015630.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000015630.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; W5L718; -.
DR Ensembl; ENSAMXT00000015630.2; ENSAMXP00000015630.2; ENSAMXG00000015191.2.
DR eggNOG; ENOG502QQ69; Eukaryota.
DR GeneTree; ENSGT00390000004153; -.
DR HOGENOM; CLU_018490_0_0_1; -.
DR InParanoid; W5L718; -.
DR OrthoDB; 4259952at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000015191; Expressed in muscle tissue and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR004776; Mem_transp_PIN-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR PANTHER; PTHR22829:SF5; INTEGRAL MEMBRANE PROTEIN GPR155; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF03547; Mem_trans; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 475..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 640..661
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 673..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 757..815
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 815 AA; 90142 MW; ABE41FC9DDA74CE4 CRC64;
MGNISTNTTV PKATPGDDPS SIPSPAMSID KLFPALLECF GIILCGYAAG RMNIITSTQA
KGLGNFVSKF ALPALLFKNM VLLDFHNVIW PFLWSILVAK LCVFFIVCVL TLLVTNKESR
FSKAGLYSIF ATQSNDFALG YPIVEALYRN NHPEYMQYIY LVAPVSLMVL NPIGFAFCEV
QKRRSEQGPQ QSKLHVVGVV LLQVLRNPIV FMVVVGIASH FILGQKIPGF MEEFVDGLAN
SFGGAALFYL GLTMVGQLRK LTRSTVVALI LLITAKLLVM PLICRGMVEV LDTGNISSLN
HSSLSNYAFL YGVFPTAPSV AIYAAHYNME LQVVTSGMVI STFLSAPIMY VSAWLLTIPW
MDPKPLASAL QNISFNISIV SLFALVWCVA VNIMSKKIHR LPHMFTFNLF MAQLGVCVGM
IAWNFVVVKD NFLGQVLTFT LLYGSLYSTY IWPGLIVLSL YLLRRDEELK VQPGFIMIVG
WGLPVLAMSI LLMVGEKMPD TIDSAFFFGT SQIVCTSLVL CVGIGLAGIS LMLLSRGTQD
YQALEQEPIT TEVLIAENTV QTRCTIEQPS IEDIRTDCQN CDCSCAPVQS VPNMVINGSV
NDSASIQTGQ CGSCCDSSQC LLVEEEQKWQ STDRQVARHV LLCLLLTVSL LANLSSCLWW
LLSTVPGRLY LELQFFCAAV NFGQGFLCFG IFGLDKHFII LPFKKRLANL RRAHGREAAG
QADVSDEIRL TCNQFLKYHK EQCVQDIVHK KKCGKRSVAE TFLGSEMVQW LQTVGLASDQ
GEALLYGSRL LEGGVIHHIT HDFGFLDDIL HYRFT
//
