ID W5L8H4_ASTMX Unreviewed; 433 AA.
AC W5L8H4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Protein FAM69B-like {ECO:0000313|Ensembl:ENSAMXP00000016136.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000016136.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000016136.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the DIPK family.
CC {ECO:0000256|ARBA:ARBA00006338}.
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DR AlphaFoldDB; W5L8H4; -.
DR Ensembl; ENSAMXT00000016136.2; ENSAMXP00000016136.2; ENSAMXG00000015675.2.
DR eggNOG; ENOG502QU5P; Eukaryota.
DR GeneTree; ENSGT00390000006452; -.
DR HOGENOM; CLU_039177_0_0_1; -.
DR InParanoid; W5L8H4; -.
DR OrthoDB; 3996595at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000015675; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR022049; FAM69_kinase_dom.
DR InterPro; IPR029244; FAM69_N.
DR PANTHER; PTHR21093:SF3; DIVERGENT PROTEIN KINASE DOMAIN 1B; 1.
DR PANTHER; PTHR21093; UNCHARACTERIZED; 1.
DR Pfam; PF12260; PIP49_C; 1.
DR Pfam; PF14875; PIP49_N; 1.
DR SMART; SM01299; PIP49_N; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..433
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017376246"
FT TRANSMEM 31..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..182
FT /note="FAM69 N-terminal"
FT /evidence="ECO:0000259|SMART:SM01299"
SQ SEQUENCE 433 AA; 48156 MW; D00C8248B6694998 CRC64;
MKPRNLRRLM HLVLFCPLSK GLQSRLPAVK VKYLVVAWLG VLVASWVIYV QYSSYSELCR
GHVCTMLICE HYRRGIISGS VCKSLCEEKT LTLQRCLSTS PTNQVYSAVW KEKAVIVKCG
IEDALGIDGS PDSFLKRDTG LYDKPTRGTS MDEFREMLHT FLKDGLGEQA SLSSLVSRVV
TLADVNSDGK VSLAEAKSVW ALLQIDEFVP MLALQDKEHA PRLLGFCGHL YATERVANAA
LFRLDVPPWL QPLVPEALSS ALNRWLAPAW PRRARITIGL LEFVEEVFHG AYGSFYMCDA
SPSRVGYNAN YDCKMADLGS VASEAAVRAF LRGRTCQTNA DCTFGRDCTA TCDRLARQCN
TEVVQPNLAK VCALLRDFLL FGAPADLLDD LDKQLRTCVT LSGLASQMEV HHSLVLNNLK
TLLWKKISDT KYS
//
