ID W5L8U7_ASTMX Unreviewed; 773 AA.
AC W5L8U7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Neurabin-2-like {ECO:0000313|Ensembl:ENSAMXP00000016259.2};
GN Name=PPP1R9B {ECO:0000313|Ensembl:ENSAMXP00000016259.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000016259.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000016259.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR AlphaFoldDB; W5L8U7; -.
DR Ensembl; ENSAMXT00000016259.2; ENSAMXP00000016259.2; ENSAMXG00000015787.2.
DR eggNOG; KOG1945; Eukaryota.
DR GeneTree; ENSGT00940000158833; -.
DR HOGENOM; CLU_007401_1_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000015787; Expressed in brain and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR040645; Neurabin-1/2_PDZ.
DR InterPro; IPR043446; Neurabin-like.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR16154; NEURABIN; 1.
DR PANTHER; PTHR16154:SF24; NEURABIN-2; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF17817; PDZ_5; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 471..559
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 747..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 643..743
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 7..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..369
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..403
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 773 AA; 85871 MW; 85C9F3AF25A49C8E CRC64;
MMKTEPPSAA SGSTSGNPLG ARSASPHRNA YEAGIQALKP VKDPAAANGD EKEGKVRATG
RGRRYGTNVH RIKNMFMQMG SPGDEEDPSK MKDQAVRLSL PRASSLNENV DHSALLKLGG
TVSERVSRFD SKGDGSGSRG SSAGSSKLQE TRKIFEQRHL QEKQAATNRI LLKKERASGF
QDSRLDVVVR FNGSTEALDR IDGDPGPADA VSPTVSQLSA VFEKAELRNN LHRPSSTSPL
PSRGVSPTPV KAAGVNSKII AKKVRTLPQT EEGQEKGILS KEQEGVPESP RRTSSQRDTS
SSNKSLVAGS AELIQAEVHV HTSLENGEAD GGHTEDKLDE DRPDSGDSHL REDEAAEEEC
HREDYSEADM VDISAYSGIG EDSGGSQLDE DEEADDDEVY EPESSCTEIS GLPVEDEPPA
SRKICFSTGP IKVFTTYSNE DYDRRNDDVD PMAASAEYEL EKRVERLDLF PVELEKDGDG
LGISIIGMGA GADMGLEKLG IFVKTVTDGG AAHRDGRIQV NDLIVEVDGT SLVGVTQNFA
ASVLRNTTGT VKFIIGREKP GEQSEVAQLI QQTLEQERWQ REMMEQRYNQ YMEEDEETGE
YATDEDEEMS PMFPNAIEVF DLAENEDMLS PVEMDPEKLA HKFKELQIKH AVTQAEIKQL
KRKLSHAEQE KLRWRMEKAQ LEQTVRETKE RMEKLEGYWM EAQALCQAVD EHLKETQAQY
QTLERKYSKA KRLIKEYQQK EIEYLKKETA QRRAQEESEV GRKEETDNLQ EKV
//
