ID W5L9S2_ASTMX Unreviewed; 1038 AA.
AC W5L9S2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=RAB GTPase activating protein 1 like {ECO:0000313|Ensembl:ENSAMXP00000016584.2};
GN Name=RABGAP1L {ECO:0000313|Ensembl:ENSAMXP00000016584.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000016584.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000016584.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5L9S2; -.
DR STRING; 7994.ENSAMXP00000016584; -.
DR Ensembl; ENSAMXT00000016584.2; ENSAMXP00000016584.2; ENSAMXG00000016106.2.
DR eggNOG; KOG1102; Eukaryota.
DR GeneTree; ENSGT00940000154611; -.
DR HOGENOM; CLU_007394_0_0_1; -.
DR InParanoid; W5L9S2; -.
DR OrthoDB; 2908929at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000016106; Expressed in brain and 14 other cell types or tissues.
DR CDD; cd01211; PTB_Rab6GAP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.10.750; Ypt/Rab-GAP domain of gyp1p, domain 1; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR PANTHER; PTHR47219:SF7; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 177..233
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 531..717
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 1..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..84
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1038 AA; 117893 MW; 5E9091AD72021FC1 CRC64;
MDDRSSLGKV GGSTESVSTV TSEEFVLVQP GAEGSPSSSE GRPRLKMSWN GSEQLERAME
EVLEDELGRE ERRGTPEEPR ESSQDLETIP APRSQKQPPS LVLNTASSEA SVSTLGSPVV
PEEDSVQFSK LSYLGCTWVK APRSEVEAQK AMATLRAESP GHIPVTLHVP NGPDGCVRIV
DQATGTEIAS FPIYKVLFCA RGKEGSLESD CFSFTESYRS SEDFQIHVFS CHIKEAVSRI
LYSFSTAFKR SSKAATDVRD SSLPQSPDSD IFAFTVSLEV REDDSKGNFS PVPKDRDKYY
FKLRQGVQKK VVVTVQQMSN KELGIERCFG MLLSPGQKVR NSDMHLLDME SMGKSADGKA
YVITGTWNPN TPAFQALNED TPKDKQVYLT VAVDLVVTEV VEPVRFLLEA LARVYPANER
FWYFSRKTFS ETFYLQLKQG IEKGSQGDAM FEVVSLQRHS ERVGGARGRL QSPTEEEEQE
EDSDSEISSG TGDVSKDCPE KILESWGGIL NRWHGNLSAR PKGLSALVRP GVPEALRAEV
WQLLSGCQDD QFLLERYRIL ITKDSAQEGV ITRDIHRTFP AHDYFKDSEG DGQDSLYKIC
KAYSVYDEEI GYCQGQSFLA AVLLLHMPEE QAFCVLVKIM YEYGLRDLYK NNFEDLHCKF
YQLERLIQEQ LPELWSHFQD MNLEAHMYAS QWFLTLFTAK FPLCMVFHIT DLLLCEGLNI
IFNVALALLK TSKEDLLQAD FEGALKFFRV QLPKRYRSAE NARRLMEQAC NIKVPTKKLK
KFEKEYHTLR ESQLQQEDPI DRYQRENRRL QEASMRLEQE NDDLAHELVT SKIALRNDLD
QAEDKADVLN KELLNTKQRL VETEEEKRRQ EEETAQLKEV FRRELEKAES EIKKTTAIIA
EYKQICSQLS TRLEKQQAAT KEELDLVKSK VMSCERCREV FNKDGPLHMP AVTQDNRDTD
VDEEKDSLKA QLRELELELA QTKLQLVEAK CRIQELEHQR GVLMNEVQAA KNSWFSKTLG
SLKTSASSQP PSSPKEGQ
//
