ID W5L9Y4_ASTMX Unreviewed; 977 AA.
AC W5L9Y4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Transient receptor potential cation channel subfamily C member 7 {ECO:0000313|Ensembl:ENSAMXP00000016646.2};
GN Name=TRPC7 {ECO:0000313|Ensembl:ENSAMXP00000016646.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000016646.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000016646.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; W5L9Y4; -.
DR STRING; 7994.ENSAMXP00000016646; -.
DR Ensembl; ENSAMXT00000016646.2; ENSAMXP00000016646.2; ENSAMXG00000016130.2.
DR eggNOG; KOG3609; Eukaryota.
DR GeneTree; ENSGT01060000248588; -.
DR HOGENOM; CLU_005716_4_2_1; -.
DR InParanoid; W5L9Y4; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000016130; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR005463; TRPC7_channel.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117:SF9; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 7; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR PRINTS; PR01648; TRPCHANNEL7.
DR SMART; SM00248; ANK; 3.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 478..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 595..617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 704..726
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 775..794
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 323..385
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 933..968
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 88..123
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 977 AA; 111654 MW; 31C193F426C0D573 CRC64;
MSDEQQEGVL EELKQQQQPH APASPPLAPG PTEDPSSHLL QLHLCPRARR ASAPLPHSTH
TLCGCGHAPS IPKPLVEVGS LLRPRQSAQK RGDAHLQHHG QRGPGGHEKH ETHYTEHGVD
PRHQRALPHT RSEIMHRRHT TLREKGRRQA VRGPAYMFNE RGTSLTAEEE RFLDAAEYGN
IPVVRKMLEE SKTLNFNCVD YMGQNALQLA VGNEHLEVTE LLLKKEGLAR VGDALLLAIS
KGYVRIVEAI LAHSSFAGGL RLTLSPLEQE LRDDDFYAYD EDGTRFSQDV TPVILASHCQ
EYEIVHILLM KGARIERPHD YFCKCHECME KQRRDSFSHS RSRMNAYKGL ASAAYLSLSS
EDPVLTALEL SNELARLANI ETEFKNDYRK LSMQCKDFVV GVLDLCRDTE EVEAILNGDV
DLIPPSEHQR PCLSRVKLGI KYEVKKFVAH PNCQQQLLTI WYENLSGLRQ QSIGVKCWTV
LGVTVGLPFL AMAYWIVPCS KLGQILRSPF MKFVAHAVSF TLFLGLLVLN ASDRFEGVKN
LPNETITDHP RQVFRVKTTQ FSWTELLIMK WVLGMIWSEC KEIWTDGPRE YVMHLWNVLD
FGMLSIFVAS FTARLMAFLK ASKAQLYIDL HVPNHDISNA SLPADVAYFT YARNKWRPSD
PQIISEGLYA IAVVLSFSRI AYILPANESF GPLQISLGRT VKDIFKFMVI FIMVFVAFMI
GMFNLYSYYL GAKYNPAFTT VEESFKTLFW SIFGLSEVIS VVLKYDHKFI ENIGYVLYGV
YNVTMVVVLL NMLIAMINNS YQEIEEDADV EWKFARAKLW LSYFDEGRTL PAPFNLVPSP
KSFYYLALKT KACLVRLCKA KSHRHDNEVE MGMLNSRPKD RYRAHSRNRE DYTLKKPIKN
PTRYQKIMKR LIKRYVLKAQ VDRENDEVNE GELKEIKQDI SSLRYELLEE KSQATAELAN
LIQQLSDKFG KNTKKQP
//
