ID W5LAR1_ASTMX Unreviewed; 566 AA.
AC W5LAR1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Hyaluronan synthase 1 {ECO:0000313|Ensembl:ENSAMXP00000016923.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000016923.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000016923.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NodC/HAS family.
CC {ECO:0000256|ARBA:ARBA00006782}.
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DR AlphaFoldDB; W5LAR1; -.
DR STRING; 7994.ENSAMXP00000016923; -.
DR Ensembl; ENSAMXT00000016923.2; ENSAMXP00000016923.2; ENSAMXG00000016438.2.
DR eggNOG; KOG2571; Eukaryota.
DR GeneTree; ENSGT00390000010337; -.
DR HOGENOM; CLU_029695_3_0_1; -.
DR InParanoid; W5LAR1; -.
DR OrthoDB; 1361850at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000016438; Expressed in heart and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR22913; HYALURONAN SYNTHASE; 1.
DR PANTHER; PTHR22913:SF4; HYALURONAN SYNTHASE 1; 1.
DR Pfam; PF13641; Glyco_tranf_2_3; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 47..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 528..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 566 AA; 66233 MW; C3C3CAD513C2099A CRC64;
MEIKPLIRRF GSIVRAFFTF LFALLVLGVV MWAYIRGIPI MSSPYGIMSF GFYGLLLSLH
LLIQSIFAFV EHRRMRARRK PCSYTKTIGF TISAFQEDPE YLRVCLQSVK ALQYPSELMR
IVMVVDGNSE DDRYMMEMFR EIFADQDPGC FVWQNNYHTW DPKAQQAWGD AGLGFEEDPQ
RREVEELISS KRCVCIMQQW GGKREVMYTA FKALGPTVDY IQVCDSDTKL DPLATVELVK
VLESNPKYGA VGGDVMILNL KDSYISFMSS LRYWMAFNIE RSCQSFFDCV SCISGPLGLY
RNDLLQQFLE SWYNQTFLGT HCTFGDDRHL TNRMLSMGYA TKYTARSKCY TETPAQFLRW
LNQQTRWTKS YFREWLYNAL WWHKHHLWMT YESIVSGVFP FFVTATIIRL FWTGTLWDIL
WVLCCIQLIG LIKAAYACIL RQKAMMVFMS LYSALYMTSL LPAKYFAILT MNKSSWGTSG
RRKIVGNYMP LLPLSIWGAV LLSGLCYTIY RESQMDWRTD GKQEEIKFLI SGAAAYVSYW
LIMCFLYWVW FRRLCRKRLQ SYNVSV
//
