ID W5LB11_ASTMX Unreviewed; 541 AA.
AC W5LB11;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=MLLT1 super elongation complex subunit a {ECO:0000313|Ensembl:ENSAMXP00000017023.2};
GN Name=MLLT1 {ECO:0000313|Ensembl:ENSAMXP00000017023.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000017023.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000017023.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00376}.
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DR AlphaFoldDB; W5LB11; -.
DR STRING; 7994.ENSAMXP00000017023; -.
DR Ensembl; ENSAMXT00000017023.2; ENSAMXP00000017023.2; ENSAMXG00000016533.2.
DR eggNOG; KOG3149; Eukaryota.
DR GeneTree; ENSGT00940000158800; -.
DR HOGENOM; CLU_036086_0_0_1; -.
DR InParanoid; W5LB11; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000016533; Expressed in camera-type eye and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd16906; YEATS_AF-9_like; 1.
DR Gene3D; 1.20.1270.290; -; 1.
DR Gene3D; 2.60.40.1970; YEATS domain; 1.
DR InterPro; IPR040930; AF-9_AHD.
DR InterPro; IPR038704; YEAST_sf.
DR InterPro; IPR005033; YEATS.
DR PANTHER; PTHR47827; AHD DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47827:SF4; PROTEIN ENL; 1.
DR Pfam; PF17793; AHD; 1.
DR Pfam; PF03366; YEATS; 1.
DR PROSITE; PS51037; YEATS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00376}; Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 449..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 477..536
FT /note="AF-9 ANC1 homology"
FT /evidence="ECO:0000259|Pfam:PF17793"
FT REGION 177..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..387
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 541 AA; 60043 MW; 68C0F623040BE637 CRC64;
LDNFMLLYSW CIKSKQFSLC TVQVKLELGH RAQLRKKVTS EGFTHDWMVF VRGPENSDIQ
HFVDKVIFRL HDSFPKPKRV CKEPPYKVEE SGYAGFLMPI EVYFKNKEEP KKVLFNYDLF
LNLEGNPPVN HLRCEKLTFN NPTRDFRRKL VKAGGIIVVP EGAEAVSRPS PDYPMLPTIP
LSAFSDPKKS KGSQLTKDNS GSSKAPKPHK LAKEHRERPR KDSESKATSK GEGDRDGSSK
SKIKVKEESK APPKAAFKEP KLTLKESKME GMSPKGGGPG AGGGGGASAD GKSASKRPSN
ADSPKPSVKK PKKGVTEGQK SSSSGGFPST SPRVSSSSAP SGYPDKKGSK DKGRWVKSKV
DTQEVKEPKK PPESDESNSD DEVSSKSEVR KRLMLLHYHP HCVPAGPLRS MVEDLQSEES
DEDDSSSDEG TPVKNNPPNR DSRSVPCSLF SSFIICLFLC AVISSCLFIY SDSFFAYTEE
LVDLHRRLMA LRERNVLQQI VNLIEETGHF NVTNTTFDFD LFSLDESTVR KLQSYLDPTA
T
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