ID W5LBT3_ASTMX Unreviewed; 895 AA.
AC W5LBT3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Si:ch73-233m11.2 {ECO:0000313|Ensembl:ENSAMXP00000017295.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000017295.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000017295.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR AlphaFoldDB; W5LBT3; -.
DR Ensembl; ENSAMXT00000017295.2; ENSAMXP00000017295.2; ENSAMXG00000016783.2.
DR eggNOG; ENOG502SBIG; Eukaryota.
DR GeneTree; ENSGT01100000263573; -.
DR HOGENOM; CLU_002274_3_0_1; -.
DR InParanoid; W5LBT3; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000016783; Expressed in zone of skin and 14 other cell types or tissues.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF15; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 14; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR SMART; SM00368; LRR_RI; 10.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 2.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 79..212
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 895 AA; 97241 MW; 6C5AA8395D48AB86 CRC64;
TDGSIDCTLH KEALRNAVLN STQASTLLGG QSINDIILNH CYTPLSASVG EEACVEESEE
WETLEAVLSR EFGEGHGGRK VMLCGGAGMG KTTGVEQLIW DWAAGTRLQH YTFLLRVCVD
TLFTSKKSLE GLLLTSHANF STEALAIVLQ RPAESLLLVL DGLDRFQNLL SECPPSDELV
NDPQQPVGGA VLLHSLLEGF LLPGASILLT SREPILDLES LQCVHLLGFS QDQRRTFAQR
FFQNEAKAEQ ILHHCEQAVG MAELCVCPTF FWMLCCVYKE CKDRAPQTLT ELCCIVTHKI
LQEHSVSMEA GKQLLCGLGK LADHCTSLTQ TSCSSTEVFA CGLQPFLGSA VLSAFLRLSG
GDISSDEATF SFLSPVFREF VSAAAFYLDP SGGIPEEGEG LLHVFLAGLS DPAQRTLLKS
SVGTFSSGRL SEFHQWLMSS VTEVLPGFEK EKHWRMFQLL HHAHSPVLVR EGVGSCQWRT
VSYSGLRVAD CVALAYIVCC LGEMEHLNLY GSKLTEKQML KLLPVFQLAR SVNLSQSHLS
SDGLRHLAQA MMDGQTTALN LSYSKLGDEA VKTLCPALKH SNLQTLNLRV CNLTPGCCEA
LGQMLSGSKL CVLDLGGNDL QDQGLSQLIS AVGTSSCRLQ DLSIGMCSLS GACVAVLSSA
LSSSLSELKI LNLRDNSLAE DTLELLSQAL QTGRSSLNTL TLFDCELTDS CCPSIAAILQ
SHNCHLTELD LSVNELGQSG ALVIFDTLTA PQCPLKKLCM VRCELTEQVF SVLGSVLVSA
TSRLKELDIG INPVGDAGAK HLWKALKHPN CKLQHLDLEM ISLTDASVDE LCEAVAASTS
LTSLILKNNG LTDLSVPRLV KLVQDRPIMK ELNLQYNDFS EDVFELMDVC PRIQY
//
