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Database: UniProt
Entry: W5LC08_ASTMX
LinkDB: W5LC08_ASTMX
Original site: W5LC08_ASTMX 
ID   W5LC08_ASTMX            Unreviewed;       898 AA.
AC   W5LC08;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 56.
DE   RecName: Full=Transcription factor E2F8 {ECO:0000256|ARBA:ARBA00039673};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000017370.2, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000017370.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU003796}.
CC   -!- SIMILARITY: Belongs to the E2F/DP family.
CC       {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR   AlphaFoldDB; W5LC08; -.
DR   STRING; 7994.ENSAMXP00000017370; -.
DR   Ensembl; ENSAMXT00000017370.2; ENSAMXP00000017370.2; ENSAMXG00000016864.2.
DR   eggNOG; KOG2578; Eukaryota.
DR   GeneTree; ENSGT00940000158651; -.
DR   HOGENOM; CLU_014845_2_0_1; -.
DR   InParanoid; W5LC08; -.
DR   OrthoDB; 1761at2759; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000016864; Expressed in testis and 9 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0001946; P:lymphangiogenesis; IEA:Ensembl.
DR   GO; GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR015633; E2F.
DR   InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR   PANTHER; PTHR12081:SF40; TRANSCRIPTION FACTOR E2F8; 1.
DR   Pfam; PF02319; E2F_TDP; 2.
DR   SMART; SM01372; E2F_TDP; 2.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU003796};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU003796};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU003796}.
FT   DOMAIN          127..196
FT                   /note="E2F/DP family winged-helix DNA-binding"
FT                   /evidence="ECO:0000259|SMART:SM01372"
FT   DOMAIN          267..353
FT                   /note="E2F/DP family winged-helix DNA-binding"
FT                   /evidence="ECO:0000259|SMART:SM01372"
FT   REGION          1..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          89..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          233..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          539..659
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          673..702
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        678..702
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   898 AA;  97326 MW;  CCD2B16A553D130B CRC64;
     MSSTLLNGQH LTQLPQTSPN KSAAANEKKT GVFVEPQTPG KTSGKSAPLE NLKIMGPLTT
     PTKGPDAPTG EPWTPTSNLK MLISAASPEI RNREKERSAD NIKADETECS SQEPELGEES
     EKLHLSRKEK SLGLLCHKFL ARYPDYPNPA INNDICLDDV ATELSVERRR IYDIMNVLES
     LHMVSRLAKN RYTWHGRAKL AQTLAALRRA GEENRYGQQM LQLKQKNLDQ EFELDGEEKE
     NEEEAEGQKE LSFISETAGD AKTAGSRKDK SLRVMSQKFV MLFLVSSPRV VSLEIAAKIL
     IGEDQVVDQD KSKFKTKIRR LYDIANVLSS LELIKKVHVT EDRGRKPAFK WTGPEDLPSP
     QDVEIATVTA SSLSSRPLES RSSLDNCTKN LFCSPGTKRG FTRHHSLVKL AKSIQDDRRK
     INSAPTSPIK MTSEAVSGGL AHLAAICKMQ LDKQTVNIPQ TPNPEDAVDV CEDTLFTSAG
     ASTAAPRESR PACSPGVHFP VLPAGAVSYL PSPCSSVIPV LLPQPQVGRS YALYVHHAPA
     RPHPSLRPPP TSLVVRSMTF ESPGGPSHKV SPAAAPAGQA AQGHDCASPS LKRACAEPAP
     EGSPSKIKRA ESSSPKLGEI LQARLKARRG ALKSSRPSSR ALHLDPEFTK PPEPRSAPLD
     QSLENFLEKE EKLQAESRET TLTPTPSRHT QKITPNGPEI QPGLTHSETL LPTGYLIPIP
     QPPLLSSSEA PKTSTPTYNI YHTPTAGSRP PPPQEFTPTG LHLPRVPPLS PFSPTPSPSI
     LNFTLQNLGL IPSPSTPTPT HAPCGVSLEP PGPAAPPGMI FVKPVSPAGT LQHGALHGQP
     VTFISLQQPL LTTPKGRPAL QHTFFHTPVS SLPTITTPTA PKTLYIPQRK LEVSSEDS
//
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