ID W5LC08_ASTMX Unreviewed; 898 AA.
AC W5LC08;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=Transcription factor E2F8 {ECO:0000256|ARBA:ARBA00039673};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000017370.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000017370.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR AlphaFoldDB; W5LC08; -.
DR STRING; 7994.ENSAMXP00000017370; -.
DR Ensembl; ENSAMXT00000017370.2; ENSAMXP00000017370.2; ENSAMXG00000016864.2.
DR eggNOG; KOG2578; Eukaryota.
DR GeneTree; ENSGT00940000158651; -.
DR HOGENOM; CLU_014845_2_0_1; -.
DR InParanoid; W5LC08; -.
DR OrthoDB; 1761at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000016864; Expressed in testis and 9 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0001946; P:lymphangiogenesis; IEA:Ensembl.
DR GO; GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR015633; E2F.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR PANTHER; PTHR12081:SF40; TRANSCRIPTION FACTOR E2F8; 1.
DR Pfam; PF02319; E2F_TDP; 2.
DR SMART; SM01372; E2F_TDP; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 127..196
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT DOMAIN 267..353
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 233..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 539..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 673..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 898 AA; 97326 MW; CCD2B16A553D130B CRC64;
MSSTLLNGQH LTQLPQTSPN KSAAANEKKT GVFVEPQTPG KTSGKSAPLE NLKIMGPLTT
PTKGPDAPTG EPWTPTSNLK MLISAASPEI RNREKERSAD NIKADETECS SQEPELGEES
EKLHLSRKEK SLGLLCHKFL ARYPDYPNPA INNDICLDDV ATELSVERRR IYDIMNVLES
LHMVSRLAKN RYTWHGRAKL AQTLAALRRA GEENRYGQQM LQLKQKNLDQ EFELDGEEKE
NEEEAEGQKE LSFISETAGD AKTAGSRKDK SLRVMSQKFV MLFLVSSPRV VSLEIAAKIL
IGEDQVVDQD KSKFKTKIRR LYDIANVLSS LELIKKVHVT EDRGRKPAFK WTGPEDLPSP
QDVEIATVTA SSLSSRPLES RSSLDNCTKN LFCSPGTKRG FTRHHSLVKL AKSIQDDRRK
INSAPTSPIK MTSEAVSGGL AHLAAICKMQ LDKQTVNIPQ TPNPEDAVDV CEDTLFTSAG
ASTAAPRESR PACSPGVHFP VLPAGAVSYL PSPCSSVIPV LLPQPQVGRS YALYVHHAPA
RPHPSLRPPP TSLVVRSMTF ESPGGPSHKV SPAAAPAGQA AQGHDCASPS LKRACAEPAP
EGSPSKIKRA ESSSPKLGEI LQARLKARRG ALKSSRPSSR ALHLDPEFTK PPEPRSAPLD
QSLENFLEKE EKLQAESRET TLTPTPSRHT QKITPNGPEI QPGLTHSETL LPTGYLIPIP
QPPLLSSSEA PKTSTPTYNI YHTPTAGSRP PPPQEFTPTG LHLPRVPPLS PFSPTPSPSI
LNFTLQNLGL IPSPSTPTPT HAPCGVSLEP PGPAAPPGMI FVKPVSPAGT LQHGALHGQP
VTFISLQQPL LTTPKGRPAL QHTFFHTPVS SLPTITTPTA PKTLYIPQRK LEVSSEDS
//