ID W5LC67_ASTMX Unreviewed; 779 AA.
AC W5LC67;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Zinc finger protein 341 {ECO:0000313|Ensembl:ENSAMXP00000017429.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000017429.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000017429.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; W5LC67; -.
DR STRING; 7994.ENSAMXP00000017429; -.
DR Ensembl; ENSAMXT00000017429.2; ENSAMXP00000017429.2; ENSAMXG00000016921.2.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00390000000546; -.
DR InParanoid; W5LC67; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000016921; Expressed in testis and 14 other cell types or tissues.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 8.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24384:SF189; DEFORMED WINGS-RELATED; 1.
DR PANTHER; PTHR24384; FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR Pfam; PF13912; zf-C2H2_6; 2.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 52..81
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 293..320
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 321..343
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 410..437
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 438..467
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 468..491
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 505..534
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 531..553
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 559..586
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 587..614
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 615..647
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 648..675
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 149..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..740
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 779 AA; 87433 MW; 217335085390B5D7 CRC64;
MSQAIFEVLE GMDNQTVLAV QSLLDGQGGV PDPSNQAVSG TTIQSMDDDD VFLCGKCKKQ
FNSLPAFMTH KREQCHPNTP SLATVSLASS NAYTSVPSIS TVSTYITVPP SPLTHTLVQG
NVLVSDEVLM SAISAFTSMD QPMAAMQAST QSHLSMPSAA SYLQHHPQSH HPLPQSQAPP
LSAQVPSSNN NSVVQVYSTL PSMTGNAEVH ALGLQPFQTV QGPSQCVESQ SQAFSSAPAY
SPAKIAIKSK PCSSTAPALT ELGEYDKVII PKKTRNTKKG QDVGQVKAKG QKLKCNFCDK
VFTKNFDLQQ HLRSHTGEKP FQCIVCGRAF AQKSNVKKHM QTHKVWPAGA HCTVSRLPIS
VKVVSVNMDE NTLQPAEQVK EFHDDVDSAS EAKGPGQAQN KQIILIDSSY QCQFCAAKFS
TYFQLKSHMT QHKEEQVYRC VVKTCSQTFQ KLDLFLEHIR THQEHLTYRC HLCCKVFPSL
FELGLHQYSH SFCPQQNRRK ETNYYRCNKC QGKYSTQEAL EQHLLTASHN YPCPHCQKIF
PCERYFRRHL STHGAVSKFK CQICKKFFKT EHYLKLHTQI HSGEKPYKCS ICEATFNRKD
KVKRHMLIHE PFKKYKCPFR THVGCTKEFN RPDKLKAHIL SHSGIKPFKC QLCQKSFSRR
AHMLEHQRSH TNNYRFRCST CSKGFSRHKY YRDHKCPLTA AASGEGGERQ RRGRSSDGKG
TEEEEEEEED EDDDDGNDEG EMTVSGVLET GTEDREEDEE EDRDEGLAAG AGLVQMQVV
//
