ID W5LCB3_ASTMX Unreviewed; 483 AA.
AC W5LCB3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Suppressor of fused homolog {ECO:0000256|PIRNR:PIRNR011844};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000017475.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000017475.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR011844}.
CC Nucleus {ECO:0000256|PIRNR:PIRNR011844}.
CC -!- SIMILARITY: Belongs to the SUFU family.
CC {ECO:0000256|PIRNR:PIRNR011844}.
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DR AlphaFoldDB; W5LCB3; -.
DR STRING; 7994.ENSAMXP00000017475; -.
DR Ensembl; ENSAMXT00000017475.2; ENSAMXP00000017475.2; ENSAMXG00000016961.2.
DR eggNOG; ENOG502QT57; Eukaryota.
DR GeneTree; ENSGT00390000009747; -.
DR InParanoid; W5LCB3; -.
DR OrthoDB; 5385318at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000016961; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 3.30.1360.230; Sufu, C-terminal domain; 1.
DR InterPro; IPR020941; SUFU-like_domain.
DR InterPro; IPR024314; SUFU_C.
DR InterPro; IPR038489; SUFU_C_sf.
DR InterPro; IPR037181; SUFU_N.
DR InterPro; IPR007768; Suppressor_of_fused.
DR InterPro; IPR016591; Suppressor_of_fused_euk.
DR PANTHER; PTHR10928; SUPPRESSOR OF FUSED; 1.
DR PANTHER; PTHR10928:SF2; SUPPRESSOR OF FUSED HOMOLOG; 1.
DR Pfam; PF05076; SUFU; 1.
DR Pfam; PF12470; SUFU_C; 1.
DR PIRSF; PIRSF011844; Suppressor_of_fused_protein; 1.
DR SUPFAM; SSF103359; Suppressor of Fused, N-terminal domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR011844};
KW Nucleus {ECO:0000256|PIRNR:PIRNR011844};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 52..228
FT /note="Suppressor of fused-like"
FT /evidence="ECO:0000259|Pfam:PF05076"
FT DOMAIN 242..472
FT /note="Suppressor of fused C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12470"
FT REGION 265..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 483 AA; 54343 MW; 38119C9FFE01B29C CRC64;
MDEMRPSSGA HLGLASIFPP GLQAIYGECR RHYPDQPNPL QVTAIVKYWL GGPDPLDYIS
MYRNMGCPAL DVQEHWHYVS LGLSDLYGDN RVHEFTGQEG PSGFGFELTF RLKREAGETA
PPTWPAELMQ GLSRYVFQSE NTFCSGDHIS WHCPLDNSES RIQHMLLTED PQMQPVQTPF
GIVSFLQIVG VCTEELQAAQ QWNGQGILDL LRGVHVAGGP WLITDMRRGE TIFDIDPHLQ
QERVDKGIET DGSNLSGVSA KCAWDDLSRP PEDEDDSRSI CIGSQPRRLS DKDTEQIREA
LRKGLEINSK SVLPPINSQR HNQDRPLQSV GHLQSKQNSR SRKDSLESES SAAIVPHELV
RTRQLESVHL KFNQESGTLL PLCLRGRLLH GRHFTYKSIN GDTAITFVST GVEGAFATEE
HPYAAHGPWL QILFTEEFVE QMLADIQDLS MHEESKLPKE YSWPDKKLKI SVLPDTVFDS
PLQ
//