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Database: UniProt
Entry: W5LCN9_ASTMX
LinkDB: W5LCN9_ASTMX
Original site: W5LCN9_ASTMX 
ID   W5LCN9_ASTMX            Unreviewed;       424 AA.
AC   W5LCN9;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 55.
DE   RecName: Full=Bromodomain containing 2b {ECO:0008006|Google:ProtNLM};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000017601.2, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000017601.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; W5LCN9; -.
DR   STRING; 7994.ENSAMXP00000017601; -.
DR   Ensembl; ENSAMXT00000017601.2; ENSAMXP00000017601.2; ENSAMXG00000017090.2.
DR   eggNOG; KOG1474; Eukaryota.
DR   GeneTree; ENSGT00940000153385; -.
DR   HOGENOM; CLU_001499_0_4_1; -.
DR   InParanoid; W5LCN9; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000017090; Expressed in brain and 14 other cell types or tissues.
DR   Gene3D; 1.20.1270.220; -; 1.
DR   Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR027353; NET_dom.
DR   InterPro; IPR038336; NET_sf.
DR   PANTHER; PTHR22880:SF240; BROMODOMAIN-CONTAINING PROTEIN 2; 1.
DR   PANTHER; PTHR22880; FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS; 1.
DR   Pfam; PF17035; BET; 1.
DR   Pfam; PF00439; Bromodomain; 1.
DR   PRINTS; PR00503; BROMODOMAIN.
DR   SUPFAM; SSF47370; Bromodomain; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
DR   PROSITE; PS51525; NET; 1.
PE   4: Predicted;
KW   Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT   DOMAIN          1..38
FT                   /note="Bromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50014"
FT   DOMAIN          252..334
FT                   /note="NET"
FT                   /evidence="ECO:0000259|PROSITE:PS51525"
FT   REGION          61..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          152..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          330..424
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        80..121
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        163..178
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..201
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..219
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        340..362
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        384..424
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   424 AA;  47188 MW;  DEA8E62F3D02058B CRC64;
     ICMKMDEREY RDAQQFSADV RLMFSNCYKY NPPEHDVVSM ARKLQDVFEF RFAKMPDEVL
     EDEEEDLEPA SLGHNMGIMG MHRSSSSSSS SSSSSSSSSS SPSSSSESEP SSESEANSDS
     SPSSDSEEER AQRLAQLQDQ VCTQLRAVHE QLAALSSAPI VKPKKKREKK KDKKKKKKLE
     KQRERERERE KEREKPSKPS KSKASKAAPS TTQSKKAPTK KNSKSNKTNK KSAAAVSRFS
     AAPAPAPVAH YDSEEEEDVL PMSYDAKRQL SLDINKLPGE KLGRVVHIIQ SREPSLRDTN
     PEEIEIDFET LKPSTLRELE RYVMTCLRKK PRKPYVAKKA GGGKSREELA LEKRRELERR
     LQDVSGQLNS VKKPQKPKVE KSSSSVEQHS VPTRLSGSSS SSDSSSSSSS SSSSSSDTSD
     SDSR
//
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