ID   W5LD64_ASTMX            Unreviewed;       840 AA.
AC   W5LD64;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 42.
DE   SubName: Full=Inter-alpha-trypsin inhibitor heavy chain family member 6 {ECO:0000313|Ensembl:ENSAMXP00000017776.2};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000017776.2, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000017776.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; W5LD64; -.
DR   STRING; 7994.ENSAMXP00000017776; -.
DR   Ensembl; ENSAMXT00000017776.2; ENSAMXP00000017776.2; ENSAMXG00000017268.2.
DR   eggNOG; ENOG502QPS2; Eukaryota.
DR   GeneTree; ENSGT00940000162980; -.
DR   HOGENOM; CLU_008101_1_0_1; -.
DR   InParanoid; W5LD64; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000017268; Expressed in muscle tissue and 8 other cell types or tissues.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR10338:SF155; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H6; 1.
DR   Pfam; PF08487; VIT; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00609; VIT; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT   DOMAIN          1..114
FT                   /note="VIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51468"
FT   DOMAIN          240..421
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          568..811
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        573..626
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        631..649
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        657..671
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        672..801
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   840 AA;  90495 MW;  B9EBDFD4A507BF28 CRC64;
     LKIMDYHVRC IVVSRYAFTT VESTVWNQLH FTKEAAFEVD LPPSAFISNF TMSNGKAYVA
     EVKERSAARR IYDAAKKQGK AAGLVATERE IEKFRVAVSV PPGVQMSFSL TFEELLTRRL
     GRYELVLGLR PGQPVQNLSL NVTIAERPGI SFIKVLSSFM FLAEAEAPSS THVQQNPHCA
     HIHYSPSLQQ QKSISAKGIN ADFVIQYDVE QNDLMGDIQV DDGYFVHYFA PRGLPVVSKD
     VIFVIDISGS MIGTKIKQTK AAMSTILGDL REGDYFNLIT FSDKVQTWKK GRTVQATKQN
     IREAREFVRK INAEGTNINA AILSAAQLVN PSSSSSQSRR HVPMIIFLTD GEATIGVTAQ
     DLILENAQSA LGSVSLFCLA FGDDADFPLL KRLSMENRGI ARMVYEDADA ALQLKGFYDE
     VASPLLSDIQ LSYMDNQAYD VTQALFPNYF QGSELVVTGK IKPGIRDLKV SLTANNSKQK
     VKVENQLGLS KAEGNWTAAS MGCTNGGLES IPSFVHRLWA YFTIKELLLA KINSTDPVVQ
     RLLMEKATNL SLKYNFVTPV TSLIVVKPDA EEPNPTTATS TTTTTTTRPA TTSVGSTANQ
     TSTANPKLST TVSTGIKTSN SISAPKAGKL PLTKPPRPHP PPPGLHTTGR PANTPPSPGK
     TVGPPSPKKT STVPPNTSRT TSSTPSTKTS TTTTSTIRTV SASSPKTTST TSLPSYPLNS
     TKPATSAIKT SATELHSTIK NTTSALPAKT TTTSSPARPL ALPSKKSASA SSPGSENSRE
     ADVPTFQADP QAVPLSTVSP EDQDTEKQED RDIATLVAAT FAPMPGLTDA PKLWEAAGIL
//