ID W5LDH3_ASTMX Unreviewed; 1626 AA.
AC W5LDH3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Kinase D-interacting substrate of 220 kDa {ECO:0000313|Ensembl:ENSAMXP00000017885.2};
GN Name=KIDINS220 {ECO:0000313|Ensembl:ENSAMXP00000017885.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000017885.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000017885.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSAMXT00000017885.2; ENSAMXP00000017885.2; ENSAMXG00000017375.2.
DR eggNOG; KOG0502; Eukaryota.
DR GeneTree; ENSGT00940000156714; -.
DR HOGENOM; CLU_001438_2_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000017375; Expressed in olfactory epithelium and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011646; KAP_P-loop.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR24116; KINASE D-INTERACTING SUBSTRATE OF 220 KDA; 1.
DR PANTHER; PTHR24116:SF1; KINASE D-INTERACTING SUBSTRATE OF 220 KDA ISOFORM X1; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF07693; KAP_NTPase; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 11.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 9.
DR PROSITE; PS50088; ANK_REPEAT; 9.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT REPEAT 45..77
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 78..110
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 111..143
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 144..176
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 177..209
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 210..242
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 243..275
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 276..308
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 342..374
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 448..958
FT /note="KAP NTPase"
FT /evidence="ECO:0000259|Pfam:PF07693"
FT REGION 888..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1236..1263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1295..1320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1394..1506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1573..1626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1236..1254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1394..1408
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1456..1482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1588..1607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1626 AA; 179846 MW; 2048BBD3126B15D1 CRC64;
MDTTSSLKMT AVAVQSIFSH IEEENLSAVR AYLDKYREVD SRSENGQTPL MAAAEQGSLE
IVQELIRRGA NVNLDDVDCW TALVSAAKEG HVEVVKELLD NNANVEHRDM GGWTALMWAA
YKGRVEVARL LLEKGANPSI TGQYSVYPII WAAGRGHAEI VRLLLQHGAK VNCSDKYGTT
ALIWAARKGH YECVMHLLEN GANVDQEGAN SMTALIVAVR GGYTEVVKEL LKRNPNVNMT
DKDGNTALMI AAIEGHTEIV EDLLDADTYV NIPDRSGDTV LIAAVRGGHV EIVRALLHKY
ADIDVKGQDS KTALYWSVEK GNATMVRDIL QCNPDTEACT KDGETPLIKA TKMRNIEIVE
LLLDKGAKVS AVDKKGDTAL HIAIKGRSRK LAELLLRNPK DGRLLYKPNK EGETPYNIDC
THQKSILTQI FGAKHLSPTE CDGDMLGYDL YSSALADILS EPTMQPPICV GLYAQWGSGK
SFLLKKLEDE MKTFAGQQVE PLLQFSWLVV VLSLLLCGSV ALILGFTVDT KLAVAVALSL
LALLYIFFVL VYFGGRKGGE SWSWAWNIST RLARHIGYLE LLLKLMFVNP PELPEQTTKA
LPVRFLFTDY NRLSSVGGET SMAEMIATLS DACEREFGFM ATRLFRVFKN DESQGKKWKK
TCCVPSFVLF ALTLACLVTG MALLAIFKVE PSNITVNAVL VAMASVVGLA LLLNCRTWWQ
VADSVLHSQR RRLHSAANSM HKLKSEGFMK VLKCEVELMA KMAKTIDGFT QNQTRLVVII
DGLDSCEQDK VLQMLDTVRV LFSKGPFISI FASDPHIIIK AINQNLNSVL RDSNINGHDY
MRNIVHLPVF LNSRGLSTAK KLSMAAPTNG DLLSAEAWHE EMDRKFQSQN SLGEQAKQGS
KTALNRRDTY RRRQMQRTVT RQMSFDLTKL LVTEDWFSDI SPQTMRRLLN IVSVTGRLLR
ANQIIFNWDR LASWINLTEE WPYRTSWLIL FLEENDIVSE QVTLKTIYER ISKNIPTTKD
VEPLLEIDGD IRSFEVFLSS RTPVLTAHDV EMFLPCTVNL DPKLREIIAD VRDAREQMHV
GGVSYPTLPL QEAPARTHSV FGQAPAACPP TASFPTQPHS SYFSGLTGPQ HPFYNRTKSQ
PPRVKQGSGA AIPPGPLSSL SIEGVCERLR HIDGLDDSML EQYTTTVKKA NINGRVLCQC
NLDELRKEMN MNFGDWHLFK AVVLEQRQVE SQLLQDECGA GSEQGSSILT QPDPTSLPPA
APQEGALHYS LNLSFEELST AGLEEPVRQP VTQWTVASHR TSSMTSLNSQ ESSNDISKLT
DRQQAEYRSA YQEYISQMAH VELEKSAQTM LGSEDKAKGG DQEACKPFKR NHKAGDSMAD
YANAQDAGLL HPITEEDEKP ERSGAGRKAA IVHGRFRSVP CQEEEEDSGP EETDATPLLW
EDHRAAGEQP LQPKAVKSFI SASTLDKKES SDSGMRSSGS SSDHSLQDDE EEEEANLPDK
AEAQQDGRLI QLELDSQAHK RLSGLQDPSV ARMSICSEAP SEGSPPASSP EENWPVSAVT
NLNRATSNVL LNNNNVDEEG PTESTPLIIG PGTATMPNQN LLGSRLMRTT SGGRDAEGAE
ERESVL
//
