ID W5LE98_ASTMX Unreviewed; 1425 AA.
AC W5LE98;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Crumbs cell polarity complex component 1 {ECO:0000313|Ensembl:ENSAMXP00000018160.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000018160.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000018160.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 7994.ENSAMXP00000018160; -.
DR Ensembl; ENSAMXT00000018160.2; ENSAMXP00000018160.2; ENSAMXG00000017623.2.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000155152; -.
DR HOGENOM; CLU_000827_2_2_1; -.
DR InParanoid; W5LE98; -.
DR OrthoDB; 2877476at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000017623; Expressed in embryo and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 14.
DR CDD; cd00110; LamG; 3.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 2.10.25.10; Laminin; 17.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF00008; EGF; 10.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF02210; Laminin_G_2; 3.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00181; EGF; 18.
DR SMART; SM00179; EGF_CA; 16.
DR SMART; SM00282; LamG; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 14.
DR PROSITE; PS00010; ASX_HYDROXYL; 8.
DR PROSITE; PS00022; EGF_1; 14.
DR PROSITE; PS01186; EGF_2; 11.
DR PROSITE; PS50026; EGF_3; 18.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1425
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017428067"
FT TRANSMEM 1363..1389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 32..71
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 72..111
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 113..152
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 154..190
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 192..228
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 230..266
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 268..305
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 307..343
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 345..401
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 403..445
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 447..487
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 487..664
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 666..702
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 708..882
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 884..920
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 948..1142
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1144..1180
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1182..1217
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1219..1255
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1275..1313
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1315..1351
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 101..110
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 142..151
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 180..189
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 218..227
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 256..265
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 333..342
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 391..400
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 477..486
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 692..701
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 910..919
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1170..1179
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1186..1196
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1207..1216
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1245..1254
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1303..1312
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1341..1350
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1425 AA; 154266 MW; 71B2469F64BE05B0 CRC64;
MGTASVRPGS LCSLVFLFFI AQWTQCVSLL KASSLCLSKP CQNGAECQDD SSTFLCQCLS
SAPGLSTASC ASNALCHPPI CQGNTTCQST SGRPGELACH CLAGLSSHSC QLSAELCART
LCGQSARCLA VAHRVPGYVC LCRPGYTGTL CQREVDQCVP NPCRNRALCR TSPEGPSCFC
VPGFQGERCE IEVNECISQP CLNGATCVDK IGHYTCLCRP GYTGVSCELE IDECQSQPCL
HGGSCHDHVN SFSCTCLDGF QGSRCEINID DCTDNQCQNG ALCIDGINSY SCDCSQSGFT
GPYCEVPLPP CWNQPCLNGA LCQEEGRNYT CECWPGFEGR HCELDVNECG SGPCLNGAVC
IERSWEKYYG TETLLPDQYD PQHAAGYVCR CPHGFTGAFC EEDIDDCASA PCHNGGLCKD
TLGGYTCVCP LESNDGVLYG GQNCSEPLVG CEGHECLNGA ACTPFLSEGL HGYSCSCLPG
YTGSHCQTST AFSFQSFGGL LSLQTPLLDY SSNLTLSFRT VLSNTLLFQR GSEGPLLTLE
LLHGHLRLSL RTESEGEGPG WALKLPQNVA DGEWHTVETV FSKGTLFLQL LEPCQSEFCG
ATAQVETGPL ILETSLKSTL IGGPADEGLT GSFIGCMRDL YVDSQLMVPE DWLSASAVNV
TRGCDHRDRC LDVPCENQGE CINLWQGYQC KCQRPYKGQN CADEYTPARF GQEGSLSYAV
FNVSDEPDPS IITLSMFLRT RQELGLLLLV TNSTSSQYLS VWLERGRIKA QFGSSQIIES
KNIVSDGESH FVSVAIEQGQ MMLLESDLVS GPVPVDSVDM QAGDKVYVAG VRDRSSLNVF
GGHFKGCIQD LRLNDEPLLF FPSNVPVKSS EPELLVNVIE GCIGDDYCTK NPCENGGMCF
SMWDDFTCAC PPSTSGLRCE VVKWCELSPC PAQAQCRTVG QGYDCISNAT FDGDMMLTYR
FNGLISRHFT NISFSIRTRK RKAVILHASR GSDFVKVSLQ DGLLVLELLS TPSSPSFSNS
SSSPLTLHST RPIADGKWHR VQLFMVEPWA NASQWTMLFP DDGEELVTSI SEVSNLDFLQ
EGVDIFLGGL ETEPDRNLYG CLSTVEISGV VLPYYGSGDV RLPRIQEEQF QKVSTESVVS
GCTGGPVCEP NPCLNGGDCK DLFDLFNCTC PSGWVGQRCE ISTDICASSP CHHGNCTAHG
LQYECVCELG YTGVNCELVV DVCAQHQCAN GGTCLHGVGQ YACLCADNFT GPYCTDRVEE
IPWYIVVKSI APKLPVSICG DEKRNYTCFN GGNCSETAFT CDCLPGFTGH RCEQEVDECK
SNPCLNGGYC RNLVNRFHCV CELSYAGETC QIDLNGESIA TELLLSVSLV SVVLFLALLA
AASALVVALN RRATRGTYSP SRQEKEGSRV EMWNIVQPPP AERLI
//