ID W5LEX9_ASTMX Unreviewed; 846 AA.
AC W5LEX9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=ANO9 {ECO:0000313|Ensembl:ENSAMXP00000018391.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000018391.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000018391.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR AlphaFoldDB; W5LEX9; -.
DR STRING; 7994.ENSAMXP00000018391; -.
DR Ensembl; ENSAMXT00000018391.2; ENSAMXP00000018391.2; ENSAMXG00000017855.2.
DR eggNOG; KOG2514; Eukaryota.
DR GeneTree; ENSGT00940000158300; -.
DR HOGENOM; CLU_006685_3_1_1; -.
DR InParanoid; W5LEX9; -.
DR OrthoDB; 534027at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000017855; Expressed in pharyngeal gill and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF37; ANOCTAMIN-9; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 250..274
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 326..344
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 390..416
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 436..454
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 485..504
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 623..645
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 788..809
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 170..236
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 239..821
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT COILED 818..845
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 846 AA; 96972 MW; CA83D90828AA607F CRC64;
MAEVGSYIGD SAAEGWTQCP GSRQRLSLRG DGVTRLERPV SLPLLEVPSE MAPQKLTKRT
GSIELLEAIG VVKKDNGTGS FSLLPGAPQS FDYVLVAQKN EDGDHESFKK QRDFINALKD
KKLKITKIVD EDRVFYGITA PNETFETYTY LLKVSDACNW SCEEQGKVPQ STRIRIVEFI
VDHTFIESSH CGAEYLSDLI KKNVFEAQFC LHEKQEQKEL KNSWARWTAC FNGQPITDVR
TYFGEKVALY FLWLGWYTFL LIPAALVGVI VFLYGLAFFK TSPLIKEVCQ SNIVMCPLCD
EKCKVWQLSD TCIYAKLSIL FDNEGTVAFA MFMAVWATVF LEFWKRHRAS YVSEWKVFDW
CEEEEELILQ IVNDADCESK KYRHSYLRST LVMILVTLML LLIIGLAHAL VVFRVIASVL
FAKPTNWAFL RENSSTVAFL MGAVLHYLTI TIMTRVNRTV AMKLCELEKV RSHAAVERSF
TVKMFVFQFF TLFSSLIYTA FFLGRINGHP GGYVRIAGIW RLEECHPSGC LTDLFIQMAV
ILILKQTINN VVEIAGPWFT RWRKRLRSRK LRQKVRQCSK RDCMESTPGA ELCDNCKVKD
LLRNFDLENV DHFSLFNEFL EMVLQFSFTT IFVAAFPLAP LLALLNNIIE IRLDAIKMVS
LERRLIPRKT NDIGIWTDVL ETIGVLAVIA NGLVIGISSD FIPRLVYRYR YGPCANSDAS
DIDCMSGYIN NSLSTANISD KNIKRDFLPA QVILSNGNNV TYCSYRDYRS NEDQSLTNQF
WVIQAVRFAF VVLFEHVVVM FKFIAGWFVP GSPLEVRNNR LQDKLNRLKE ELRAERKRHK
EKSQDK
//
