ID W5LGQ7_ASTMX Unreviewed; 747 AA.
AC W5LGQ7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Protein VAC14 homolog {ECO:0000256|ARBA:ARBA00013840};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000019019.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000019019.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Microsome membrane
CC {ECO:0000256|ARBA:ARBA00004524}.
CC -!- SIMILARITY: Belongs to the VAC14 family.
CC {ECO:0000256|ARBA:ARBA00010225}.
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DR AlphaFoldDB; W5LGQ7; -.
DR Ensembl; ENSAMXT00000019019.2; ENSAMXP00000019019.2; ENSAMXG00000018451.2.
DR eggNOG; KOG0212; Eukaryota.
DR GeneTree; ENSGT00390000008385; -.
DR HOGENOM; CLU_007740_1_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000018451; Expressed in intestine and 14 other cell types or tissues.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070772; C:PAS complex; IEA:InterPro.
DR GO; GO:0006661; P:phosphatidylinositol biosynthetic process; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026825; Vac14.
DR InterPro; IPR021841; VAC14_Fig4p-bd.
DR PANTHER; PTHR16023:SF0; PROTEIN VAC14 HOMOLOG; 1.
DR PANTHER; PTHR16023; TAX1 BINDING PROTEIN-RELATED; 1.
DR Pfam; PF12755; Vac14_Fab1_bd; 1.
DR Pfam; PF11916; Vac14_Fig4_bd; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022848};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Microsome {ECO:0000256|ARBA:ARBA00022848};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 510..688
FT /note="Vacuolar protein 14 C-terminal Fig4-binding"
FT /evidence="ECO:0000259|Pfam:PF11916"
FT REGION 330..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 747 AA; 84763 MW; 9119C69E5CDB05D0 CRC64;
MNTEKDFSPL TPNIVRALND KLYEKRKVAA LEIEKLVREF VAQNNSTQIR HVIQILASEF
ALSQHPHSRK GGLIGLAACS IALGKDSGLY LKELIEPVLT CFNDSDSRLR YYACEALYNI
VKVARGAVLP HFNVLFDGLS KLAADPDPNV KSGSELLDRL LKDIVTESNK FDLVAFVPLL
RERIYSNNQY ARQFIISWIL VLESVPDINL LDYLPEILDG LFQILGDSSK EIRRMCEVVL
GEFLKEIKKT PSSVKFAEMA NILVIHSNDL IQLTAMTWMR EFIQLAGRVV LPYSSGILTA
VLPCLSYDDR KKITKEAASA CNHSLMKLVT PEDDEDEEES QSTTSPPSKD TSTKKEGDIN
GKISNLADRS QVTLDLDGIV QVLDRHLHDS LTGMMTRIAV LKWLYHLYIK TPRKMFRHTD
SLFPMLLKTL SDESDEVILK DLEVLAEIAS SPAGQTESLG SCDGSDKTEL HVPDGSAGSK
VADSSPSTPS MNSYFYKFMI NLLQRFSLER KLLETRGAFI IRQLCLLLHA ENIFHSMADI
LLKEEDLKFA STMVQTLNTI LLTSAELFQL RNQLKDLRTP ESCTLFCCLY RSWCHNPVAT
VSLCFLTQNY RHAYDLIQKF GDLEVTVDFL IEVDKLVQLI ESPIFTYLRL QLLDVENNPY
LIKALYGLLM LLPQSQAFQL LSHRLRCVPN PELMRTVEIP KPVSAKRATR PQVDYKELLQ
HFEHVQSKHL EVRHQRVGHT EHPDRKL
//
