ID W5LGW1_ASTMX Unreviewed; 815 AA.
AC W5LGW1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=MDM2 binding protein {ECO:0000313|Ensembl:ENSAMXP00000019073.2};
GN Name=MTBP {ECO:0000313|Ensembl:ENSAMXP00000019073.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000019073.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000019073.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; W5LGW1; -.
DR STRING; 7994.ENSAMXP00000019073; -.
DR Ensembl; ENSAMXT00000019073.2; ENSAMXP00000019073.2; ENSAMXG00000018512.2.
DR eggNOG; ENOG502RGBH; Eukaryota.
DR GeneTree; ENSGT00390000003305; -.
DR HOGENOM; CLU_017071_0_0_1; -.
DR InParanoid; W5LGW1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000018512; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0031396; P:regulation of protein ubiquitination; IEA:InterPro.
DR InterPro; IPR039061; MTBP.
DR InterPro; IPR029418; MTBP_C.
DR InterPro; IPR029420; MTBP_central.
DR InterPro; IPR029421; MTBP_N.
DR PANTHER; PTHR14382; MDM2-BINDING PROTEIN; 1.
DR PANTHER; PTHR14382:SF1; MDM2-BINDING PROTEIN; 1.
DR Pfam; PF14920; MTBP_C; 1.
DR Pfam; PF14919; MTBP_mid; 1.
DR Pfam; PF14918; MTBP_N; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 2..217
FT /note="DM2"
FT /evidence="ECO:0000259|Pfam:PF14918"
FT DOMAIN 227..553
FT /note="DM2"
FT /evidence="ECO:0000259|Pfam:PF14919"
FT DOMAIN 739..806
FT /note="MDN2-binding protein C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14920"
FT REGION 492..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 815 AA; 89332 MW; 6205CB6BE005A4EC CRC64;
SRRIYDKLVE ISSSSSSSEL PPFPACSLSG SPGLQKCYFA VQMTYGLAQF CSAEWEEVCV
ERSDSEETAP SAVDSCISAV QDQEESESTT LTELFEEAAE ALHQLADKLP PPGHFLLDVL
MLCEDKEGLK EFLPVIGALK HMQAWHSALV NIVTEHSTGW RTAASYLSAR VRSPAEALDC
IDERELWRGG LWLRERKFVS ELVFEGFSLK VQSRSSWSRV LNPERLVFHY YQPVMELIQL
VNVADFPMLL QSSTEFELTM SSRSARARLF YDQLRTLRGG MGALFALSCV ISTEAFPPAS
QLSASRWRDF MSKRPKVLSV PEVELKGEKG HYLLLVQGVE SGGCKARLMH SANQINGTVA
LGMINGLIRE TLLSSSGDAW LQSLPRLHGE QLLHREKGVD RVQMRVLQEW LRRREEVQKP
AALPLNELKV LLNLAREQYL NTQNTTLPRV SDSEPAEPKH TRLTQTAMKN TSSSDWPERS
VLRNYENMQK IRHRSRSSLF SGGSSDSLMG PKDGPKSGSA QLDARELLRH FTPDGLPAGE
LQPLPVLRGE NAFQMSSDIT PRKVTKLPFT QASSSHYHAP LCSTSITTSA HLQHHSAHLH
SPLCSPPSPL CSPPSPLCSP PSPSPLCSPP SPLCSPPSSS LLCSPPSPLC SPPSPLCSPP
APLCSTSITT CSPPSPLCSP PSPLCSPPSP LCSPPSPLCS PPSPLCSPPS SSPLCSPPSP
LSSPPSPSPL CSPSSPLCSP HHHSMLKEVV LKTLKHHGIS SDHKCFQTCS RRLFDVSKLY
LKDLKTSRGL HEEMKKAAGR NAKQVIDWVM EKDGL
//
