ID W5LH00_ASTMX Unreviewed; 359 AA.
AC W5LH00;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Pleckstrin homology domain-containing family A member 1 {ECO:0000313|Ensembl:ENSAMXP00000019112.2};
GN Name=PLEKHA1 {ECO:0000313|Ensembl:ENSAMXP00000019112.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000019112.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000019112.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; W5LH00; -.
DR Ensembl; ENSAMXT00000019112.2; ENSAMXP00000019112.2; ENSAMXG00000043373.1.
DR eggNOG; ENOG502QT2K; Eukaryota.
DR GeneTree; ENSGT00940000155157; -.
DR HOGENOM; CLU_055135_2_1_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000043373; Expressed in olfactory epithelium and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd13271; PH2_TAPP1_2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR14336:SF4; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 1; 1.
DR PANTHER; PTHR14336; TANDEM PH DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 165..263
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 359 AA; 40445 MW; 75D50BE2C7D14681 CRC64;
MPYVDRQNRI CGFLDIEENE NSGKFLRRYF ILDTLEGSLV WYMDNPQNLP VGTACVGSLK
LTYISKVSDA TKLRPKAEFC FGKPVLVYLT VGRLQVPKSG EHSVQNPAEA CVEVLGTMKQ
VSYKTEIIGG VPIITPTQNG ADRGTVRKPH GQMPYYLSRA NQDQSVVKAG YCVKQGAVMK
NWKRRYFMLD DNAISYFKSD LDREPLRMIP LKEINKVQEC KQSELMMRDN LFELVTTSRT
FYIQTDSPED MHSWIKAISG AIVAQRGPGR SAATMRQARR FSNPCIQRYT SRNGECSTYV
LSSNPGAPPT SPVLFCILAV QYNAVDFSVF LASLLFNPPQ NQIKTSHNHY LAHQCHAST
//
