ID W5LJN2_ASTMX Unreviewed; 746 AA.
AC W5LJN2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=vesicle-fusing ATPase {ECO:0000256|ARBA:ARBA00012674};
DE EC=3.6.4.6 {ECO:0000256|ARBA:ARBA00012674};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000020044.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000020044.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000161};
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|ARBA:ARBA00006914}.
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DR AlphaFoldDB; W5LJN2; -.
DR STRING; 7994.ENSAMXP00000020044; -.
DR Ensembl; ENSAMXT00000020044.2; ENSAMXP00000020044.2; ENSAMXG00000019442.2.
DR eggNOG; KOG0730; Eukaryota.
DR GeneTree; ENSGT00940000166147; -.
DR HOGENOM; CLU_000688_12_3_1; -.
DR InParanoid; W5LJN2; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000019442; Expressed in muscle tissue and 9 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd19528; RecA-like_CDC48_r2-like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.10.330.10; -; 1.
DR Gene3D; 6.10.20.150; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR004201; Cdc48_dom2.
DR InterPro; IPR029067; CDC48_domain_2-like_sf.
DR InterPro; IPR003338; CDC4_N-term_subdom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23077; AAA-FAMILY ATPASE; 1.
DR PANTHER; PTHR23077:SF63; TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE; 1.
DR Pfam; PF00004; AAA; 2.
DR Pfam; PF17862; AAA_lid_3; 2.
DR Pfam; PF02933; CDC48_2; 1.
DR Pfam; PF02359; CDC48_N; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01072; CDC48_2; 1.
DR SMART; SM01073; CDC48_N; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF54585; Cdc48 domain 2-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00674; AAA; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 1..63
FT /note="CDC48 N-terminal subdomain"
FT /evidence="ECO:0000259|SMART:SM01073"
FT DOMAIN 80..146
FT /note="CDC48"
FT /evidence="ECO:0000259|SMART:SM01072"
FT DOMAIN 180..316
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 453..592
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 708..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 746 AA; 83256 MW; 76D0E8CD6BEA4BA5 CRC64;
MEELQLFRGD TVVMRGRKRR QTVCIVLTDD TCGDERIRMN RVTRNNLRVR LGDVISINAC
PDVKYGKRIH VLPIDDTIEG LTGNLFEVFL KPYFLEAYRP VHKGDIFLVR GGMRAVEFKV
VETDPTPHCI VAPDTIIHCE GEPIKREVVY GFGRYSFVML FYTLCVTLQH ARLFSSKRVP
PRGILLYGPP GTGKTLVARA VANETGAFFF LINGPEIMSK LAGESESNLR KAFEEAEKNA
PAIIFIDELD AIAPKREKTH GEVERRIVSQ LLTLMDGLKQ RVHVVVMAAT NRPNSVDPAL
RRFGRFDREI DIGIPDSTGR LEILQIHTKN MKLADDVDLE RIATDTHGHV GADLAALCSE
AALQAIRKKM TLIDLEDETI DADLLNSLAV TMDDFRWALS QSNPSALRET VVEVPQVNWE
DIGGLDEVKR ELQELVQYPV EYPDKFLKFG MTPSRGVLFY GPPGCGKTLL AKAIANECQA
NFVSIKGPEL LTMWFGESEA NVRDVFDKAR QAAPCILFFD ELDSIAKSRG GGAGDAGGAA
DRVINQILTE MDGMTNKKNV FIIGATNRPD IIDPAILRPG RLDQLIYIPL PDMPSRTAIL
RANLRKSPVA KEVDLPYLSR ITEGFSGADL TEICQRACKL AIREAIEAEI RAERERQSRK
GTDDDYDPVP EIRKDHFEEA MRFARRSVSD NDIRKYEMFA QTLQQSRGFG NFRFPSSSQS
GGGQGQGSGQ GSGGHYREDG DDDLYQ
//
