ID W5LK77_ASTMX Unreviewed; 681 AA.
AC W5LK77;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Selenoprotein O {ECO:0000256|ARBA:ARBA00031547};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000020239.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000020239.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the SELO family.
CC {ECO:0000256|ARBA:ARBA00009747}.
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DR AlphaFoldDB; W5LK77; -.
DR STRING; 7994.ENSAMXP00000020239; -.
DR Ensembl; ENSAMXT00000020239.2; ENSAMXP00000020239.2; ENSAMXG00000019652.2.
DR eggNOG; KOG2542; Eukaryota.
DR GeneTree; ENSGT00390000005508; -.
DR HOGENOM; CLU_010245_2_1_1; -.
DR InParanoid; W5LK77; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000019652; Expressed in muscle tissue and 5 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR HAMAP; MF_00692; SelO; 1.
DR InterPro; IPR003846; SelO.
DR PANTHER; PTHR12153:SF15; PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12153; SELENOPROTEIN O; 1.
DR Pfam; PF02696; SelO; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ SEQUENCE 681 AA; 75902 MW; 876EC51BBAA21ED9 CRC64;
MTRGSRVSRN PPVQPREATG SVCALVFTTM AQTGQTPLQR LSFNNVALRR LPVDGSLEPG
SRTVRAACFS RVQPQPLLRP RFVAVSPRAL ALLGLSAEDV LADPRGAEYL SGSRVLPGSQ
PAAHCYCGHQ FGVFAGQLGD GAVCYLGEVE AARSSDPQPR SPCGRWEVQV KGAGLTPYSR
QSDGRKVLRS SIREFLCSEA MFSLGIPTTR AGSLVTSDLF VKRDAFYSGK PERCSVVLRI
APTFIRFGSF EIFNPADDFT GRQGPSAGRH DIRAQLLDYV IETFYPEIQA DHTDRKARNA
AFFREVTVRT ARLVALWQSV GFCHGVLNTD NMSILGLTID YGPFGFMDRF DPEFVSNASD
KKRRYTFEAQ PYVCRWNLAR LAEALGTELK GSTAGSILDE FIPLYKSFYL DNMRRKLGLV
RREEPEDEEL VEDLLKVMHN TGADFTNTFR LLSRVCCPLV EENSECDVGS VVNLILEQCA
SLQELKVANH PTMEPCELEM ILSMAETSPG LFNMTANRPE VAKQLEKIGR LKELLETNQE
DLKLKQRDDW WIWINRYRKR LTRESDGVSD PTAVEEERVR IMDSTNPAVV LRNYLAQNAI
EWAENGDFSE VQRLLGVLEN PYCVQPDLKL PICPGKGAPC ETRGSTGLNV EDGREEQGTI
GTGCLPYNSK PPEWAREICV T
//
