ID W5LKB7_ASTMX Unreviewed; 1076 AA.
AC W5LKB7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Hephaestin-like 1a {ECO:0000313|Ensembl:ENSAMXP00000020279.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000020279.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000020279.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the multicopper oxidase family.
CC {ECO:0000256|ARBA:ARBA00010609}.
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DR AlphaFoldDB; W5LKB7; -.
DR STRING; 7994.ENSAMXP00000020279; -.
DR Ensembl; ENSAMXT00000020279.2; ENSAMXP00000020279.2; ENSAMXG00000019667.2.
DR eggNOG; KOG1263; Eukaryota.
DR GeneTree; ENSGT00940000155866; -.
DR HOGENOM; CLU_005569_0_0_1; -.
DR InParanoid; W5LKB7; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000019667; Expressed in heart and 14 other cell types or tissues.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006825; P:copper ion transport; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.420; Cupredoxins - blue copper proteins; 3.
DR InterPro; IPR011707; Cu-oxidase-like_N.
DR InterPro; IPR011706; Cu-oxidase_C.
DR InterPro; IPR045087; Cu-oxidase_fam.
DR InterPro; IPR033138; Cu_oxidase_CS.
DR InterPro; IPR002355; Cu_oxidase_Cu_BS.
DR InterPro; IPR008972; Cupredoxin.
DR PANTHER; PTHR11709:SF233; FERROXIDASE HEPHL1; 1.
DR PANTHER; PTHR11709; MULTI-COPPER OXIDASE; 1.
DR Pfam; PF07731; Cu-oxidase_2; 2.
DR Pfam; PF07732; Cu-oxidase_3; 3.
DR SUPFAM; SSF49503; Cupredoxins; 6.
DR PROSITE; PS00079; MULTICOPPER_OXIDASE1; 3.
DR PROSITE; PS00080; MULTICOPPER_OXIDASE2; 1.
PE 3: Inferred from homology;
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1076
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017257496"
FT DOMAIN 97..203
FT /note="Plastocyanin-like"
FT /evidence="ECO:0000259|Pfam:PF07732"
FT DOMAIN 267..359
FT /note="Plastocyanin-like"
FT /evidence="ECO:0000259|Pfam:PF07731"
FT DOMAIN 455..559
FT /note="Plastocyanin-like"
FT /evidence="ECO:0000259|Pfam:PF07732"
FT DOMAIN 809..902
FT /note="Plastocyanin-like"
FT /evidence="ECO:0000259|Pfam:PF07732"
FT DOMAIN 956..1059
FT /note="Plastocyanin-like"
FT /evidence="ECO:0000259|Pfam:PF07731"
SQ SEQUENCE 1076 AA; 121127 MW; 18D28A2525339827 CRC64;
MSGARLYALL ICLAALLSLS HSRTRTYHIG IREEEWDYAP GGKNFISGLD ISEDQYASVF
LEHSETRIGS KYKKAVYRQY TNEQFTTEIP KPEWLGFLGP VIRAEVGDDI EVHMKNFASR
PYSIHPHGVF YEKDSEGALY PDGTSGQNKA DDAVAPGQSY TYKWKVKEEF APMESDSTCL
TWIYHSHVDA PKDIAAGLVG VLLTCKKGTL DSSGLKRSDV DQEFFLMFSV VDENLSWYLN
DNINKSCNAT ERAFLEEDDF HESNLMHSIN GYVYGNLPTL SVCIGKPVSW HLFGIGSEVD
IHSVHFHGHT LLDRGHRSDV LSLFPASFVT AEMVPKTPGK WMLSCQVNDH TRAGMQAFYQ
VSHCQNLSST TVSSGHERHY HIAAEEQMWD YAPTGKDAFN NDQALNTTHS DSEEFFTKEG
GKLGGKYLKA RYVLYADDTF TTKMLPHGSE QHLGILGPVI RAETGDVIVV TFKNKAKRNY
SMQPHGLHYD KAYEGAMYQD GSQKRGASVA PGQTFTYRWH VMEGPSSPSD PPCLSYLYYS
ATDLVRDTSS GLVGPIQVCK KGVLDESGRQ HLGSEVQKEF FLLFTVFDEN ESWYLHDNIA
RFGSSKTYPE DEGFMESNKM HSVNGLMYGN LHGLDLCEGD HVVWHTLGLG TEVDLHGVHF
QGNTFQRDGT TRDTLSLLPH TSVTVSMIPN NDGVFELSCL TTDHHRGGMR QKYTVKQCSP
SPVSKAVNTK IDRTYYLAAE EVEWNYAPNR TWELEKHNTI EEDSLGKVFL GKSDHQIGPV
YKKVVFRQYT DKTFTTKKSR SPEEEHLGIL GPILRAEVGE VVQVVFKNKA KQRWYSVHAH
GVKTSEAHLK PVSPGEEISY NWTISAGPGP AESNCTTFAY YSSANFVKDL ASGLVGPLVV
CRKGTLKEEN RRNDVDKEFA LLFMVFDENE SWYLKENVDT YIKNAPENLT DDENFIESNM
MHGINGKLYA NLHGLDMDKG DRTEWYLIGL GNEMDMHTVH FHAQSFVYRT DHSHRADVYD
LLPGTFQTVE LVAGTPGTWL LHCHVTEHIH AGMETTFTIH GQQQSLFQKS CPGLLY
//
