ID W5LKD3_ASTMX Unreviewed; 1246 AA.
AC W5LKD3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Immunoglobulin superfamily DCC subclass member 4 {ECO:0000313|Ensembl:ENSAMXP00000020295.2};
GN Name=IGDCC4 {ECO:0000313|Ensembl:ENSAMXP00000020295.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000020295.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000020295.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5LKD3; -.
DR STRING; 7994.ENSAMXP00000020295; -.
DR Ensembl; ENSAMXT00000020295.2; ENSAMXP00000020295.2; ENSAMXG00000019505.2.
DR eggNOG; KOG4221; Eukaryota.
DR GeneTree; ENSGT00940000159637; -.
DR HOGENOM; CLU_006906_0_0_1; -.
DR InParanoid; W5LKD3; -.
DR OrthoDB; 5397809at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000019505; Expressed in liver and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 5.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF39; FI24025P1; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS50835; IG_LIKE; 4.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1246
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017375251"
FT TRANSMEM 926..949
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..118
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 125..217
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 220..307
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 317..403
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 413..507
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 509..606
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 612..715
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 725..818
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 823..918
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1053..1082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1101..1246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1053..1067
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1068..1082
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1135..1194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1196..1213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1229..1246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1246 AA; 135369 MW; 3AF3894B08C8AE51 CRC64;
MALKNSCWLF CLLLLSLGCC GLSPQENSVS VELSCGAGPV HVILEPPDPV LLDCHLGATE
YPLNITWLRD GVVLSESEAV QLLPNGSLLV LPSSRDVEGA YSCLSGSSFG ALTSRTVTLQ
LASLSRFLQD PEPQVVPESN TARFECHVEG LPTPSITWEK DQAPLPEQTD PDDAPRYVTL
PNGVLQVLGV SKDDEGLYRC VASNSARKRY SQEASLTVTP GTTEESEVVI TAPPRDLTVV
LGQPAVLECM AQGQPKPFVS WSRQDGKPIS TDVVVLATNL VIPDTQSQHA GVYVCRANKP
KTREFVSASA HIRVLAPPVI LQPPESRALS RANTARFVCN SSGDPAPVLR WLKNGEPVQW
SARVKTQSPG VLLINQLGLE DAGYYQCIAS NSLGTACATA KLLVIVKQGL PSPPQRLQAT
PHSSTSALLT WEPPESNSDQ VIGFSIHYQR ATGSDNMEYQ FAVNNDTTEF HVKELQPHTA
YTFYMVAYSP MGASHPSQSV TVEMLEDVPS ASPQLSLLST SPTEIRVMWL PLSLQLSRGA
ITRYRIDYRT LEQDEDVFSV EVGGNETQAT LKDLKPNHTY QLRMAAGTRA GFSQPSEWAI
HHTPNLTQVL FAPTELKVRA KMRSLHVTWQ PPPNPTQITS YKLAYREVEA EEPANEETPV
ADSHQIRLRK RVKHYEITGL APDRLYEVKV WACNKQTEGY PAVWKGRTEK FTDPVRLPDY
LPPLPPSSVK AQANSSTSIW LRWEKPPFSN VRIITYTIRC SPAGTRNASL VSYYTSTSQE
ILLGALKPFT RYELAVQSNG INMGGPFSST VEESTLADRP SSPPTDLQLT AINPFSVFVS
WRPPLEPNGI IVSYRMLYSG NLSQPDYLWN NLSHDGSITS TEVLGLMSGT CYYFKMGACT
EVGVGPFSTV KDVHTPQKPY ELDIPAVTGI IVGVCLGLLC ILLCMCVSFR NGKSQEASGV
LEQSALSSQY RRGGHPVSTA VSDCTDCHEL ETLMPPLTRD PALPLTEPNE HQTLMGSGGA
ADDPAEPKVT WNGSVRRDWT NRITRYRDTI TEDSPSLING SRDVSANENS KNGHEERLHS
LGSNRVEAEV IVHSELSEAV DGVQSDTDLS LGSPVSQAPS NGEEGPPQSP TTHPAPSLSA
PETQPSSPPI SNHTQEVLSN HNGPLENSGP VQTTVGGAKL KGTSLTNGFH SPESLRPSRE
SLENGDHRLC PKKKALSQPG LPSSPPAFAT PGLVQSTSGA HGYLCS
//
