ID W5LKS9_ASTMX Unreviewed; 653 AA.
AC W5LKS9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000020441.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000020441.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; W5LKS9; -.
DR Ensembl; ENSAMXT00000020441.2; ENSAMXP00000020441.2; ENSAMXG00000019857.2.
DR eggNOG; ENOG502S196; Eukaryota.
DR GeneTree; ENSGT01100000263529; -.
DR HOGENOM; CLU_002274_0_1_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000019857; Expressed in embryo and 7 other cell types or tissues.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106:SF151; B30.2/SPRY DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 30..165
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 653 AA; 74616 MW; 2696A07F244F8654 CRC64;
MEGFYPKPGE TSVNFSEIFK VQSGENKSGT KVLTLGIAGV GKTASVHKFI LDWAEERHNQ
DLDFILFLPF RELNLIKENS LRLSDLLHYF HPELYIEDVM EILNGKYTVA LILDGLDESK
IPLNFNQEKV LNAQAKISLN KLLTGIIKGE LLPTAVIWIT SRPAAANQIP RKYFLIITEI
HGFNDSQKEE YFRKRIQNQD EASRIISHIK AARSLHILCH IPVFCRISVS VLQEMIKKDK
EMENAPTTLT EMYIRFLIFH TRQKSEKYNP EQNVDGAVPS SKREKMEAES VLKLAKLAFL
QLQKEQLIFY EEDLKECDIE VEEAVVHSGV CTQIFKKDEK FYSFVHLSFQ EFLAAVFVFI
TSSDESNPLF QTWWEKIKWR YKHTLDNLLK TAVEKAMKSK NGHLDLFLRF LFGLTLESNQ
RLLKSLQPEI EINKEDLKGT IGYIKRKLKK KKSSEKTINL FHCLSEMKDT SLTGEIQKFL
NSGTLSTQEL SSTQWSALVF VLMMSEETQE KFELKKYRAS EEGLRRLLPV VKNTRRALLD
HCSLSKNACE TLASVLISDS ALIELDLSNN DLQDSGVELL SAGLKSSHCK LQILRLSGCM
ITEKGCSSLS SALSSNPSHL KELDLTYNHP GESGELSARL KDPHCSLETL RYE
//