ID W5LKY5_ASTMX Unreviewed; 2241 AA.
AC W5LKY5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Nuclear receptor corepressor 2 {ECO:0000313|Ensembl:ENSAMXP00000020497.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000020497.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000020497.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family.
CC {ECO:0000256|ARBA:ARBA00010097}.
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DR STRING; 7994.ENSAMXP00000020497; -.
DR Ensembl; ENSAMXT00000020497.2; ENSAMXP00000020497.2; ENSAMXG00000019886.2.
DR eggNOG; KOG1878; Eukaryota.
DR GeneTree; ENSGT00940000159022; -.
DR HOGENOM; CLU_000922_0_0_1; -.
DR InParanoid; W5LKY5; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000019886; Expressed in camera-type eye and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0060218; P:hematopoietic stem cell differentiation; IEA:Ensembl.
DR GO; GO:0030225; P:macrophage differentiation; IEA:Ensembl.
DR GO; GO:0030223; P:neutrophil differentiation; IEA:Ensembl.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.20.5.430; -; 1.
DR Gene3D; 1.20.58.1880; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR031557; N-CoR_GPS2_interact.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR PANTHER; PTHR13992; NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR; 1.
DR PANTHER; PTHR13992:SF21; NUCLEAR RECEPTOR COREPRESSOR 2; 1.
DR Pfam; PF15784; GPS2_interact; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
DR PROSITE; PS51293; SANT; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 428..444
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 562..613
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 565..609
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 566..613
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 878..939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1239..1260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1273..1483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1596..1890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1911..1934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1986..2022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2063..2086
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2102..2241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..639
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..670
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..702
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..787
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..904
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..939
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1047
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1325..1339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1367..1385
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1389..1405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1418..1432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1617..1642
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1645..1698
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1712..1788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1813..1838
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1870..1888
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2004..2022
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2137..2153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2162..2179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2186..2203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2241 AA; 249016 MW; B92ED4BFC7CE529E CRC64;
MSSHPQPVPQ SRRAVDARHL PNPAGLPLQL ARAHTDVGMV DFHPRDYTSH LAHGSLSQPH
RRRPSLLSEF QPGTQEPHVR YEHIYLQEAN SQSEVEYSEI KRPRLEIGAD SLMRHQSHRQ
PLSLGGAEDL AKERSSSSSM GKLEPVSPVS PAEPDLDLVP TRFSKEELIQ NMDRVDREIT
MVEQQICKLR KKQQQLEEEA AKPQEPERSI SPPPSEAKHR SLVQIIYDEN RVRAIPLYNQ
PSDTKQYHEN IKINQVMRKK LILYFKRRNH ARKQWEQKFC QRYDQLMEAW EKKVERIENN
PRRRAKESKV REYYEKQFPE IRKQRELQER MQSRVGQRGG LASAARSEHE VSEIIDGISE
QENSEKQMRQ LAVIPPMLFD AEQQRIKFIN MNGLMDDPMK IYKDRQVMNM WSDQEKNTFR
EKYVCVCTVA ECVLFYYLTK KNENYKNIVR RNYRRRGRSQ QQQQQQQQVN RNHQEEKEDK
EKEKEAEREE DKTEGDDKED GIKDDTSGED GEDKEPPVAV KGRRTANSRG HRKGRITRSM
ANEQEETSSP PLSNELANLE MNESSRWTEE EMETAKKGLL QYGRNWSSIA KMVGSKTVSQ
CKNFYFNYKK RQKLDEILQQ HKMKSEQERK ARRKGKALQS EEASAPSAAD EEEMEGSGVS
GNEEEAQEDG EGGLNNSSDT ESLPSPRSSE DSKVKEENSS HSKTKPSAPS SSSSSSSEKE
PSAQEQEEKP VIQVEQVGVK EEEQSEGVEG AREVPSETED KKPPTLEPEE GKRESRKRDR
EHGGKSGGQD SDSSATCSAD EAEDADGADK NRPSLLSYAH DGVISTALQK PLDLKQLKQR
AAAIPPIMPE VSSAGVLGKH QVLPDALALY EQQITMAHES SQEAKQQQQQ QQQQQQQQPQ
PVKLQHYPGG SGGRDTSSPR VRTRSPTPSE REKEELEGKE RWLQTLLHGL YKPRAFSPLA
DIKKTPEDLR AVCVGRPVMS PFQLSPRDMA KLSHEQLLHY NSSTTLQQQE RMSAVRPLHI
PEPPPLISSA KPGGSITQGT PVQMHSPAHG SEHTKLSAPG SQPLSWMMDQ RKIGGFPMVK
QEQLSPRGPS SSQAENLSSQ KKLFIAGPMP AVQGGSITKG LPGTRVHQDP PISYRGGSIT
QGTPADVLYK GTITRLITED NPSRDRAREE SQAKGHVVYE GLSGHILSYD RTPNTKEDGR
GEVLGLKRPY DVMEGGLSRV LPLRDSMPTA EGLIGRAMPQ ERESPHPHHM RGSISQGIPR
HVEDQEYLRR EAKQLKRDSP SPRGPALGSD PLKGRTHESH VPTVKEPGRS IHLIPPESVV
MSKPPKEGSI TQGTPLKQDP AGSSKRHDVR SIIASSPRPY AGLPPHLELR PEHRGSERGR
YEDQGPKSRP SAVVSTSSSL ARASPLSLAA EQGSKAHHSP VGYEEHKRSS YPPASHRGSP
LSSRDTPQRP HEGSSKVPQQ ERKSTPTPRE VSATKSPLPG VAEHPASLAS YERLLQGLGA
DMYRGPIPLP FDPSTLPRGI PIDPAAYYLP RHLAPTPGYP HHYQPYIIRG FPDTAALENR
HTLFTDYITS QQMHQWPAAA MAQRPDLLRG LAPREQPLTL PYSPTPRGAS ASPMDRITYI
PGTSTSFPSR AYTTSPISPG TGTHCVQERE RDRERDRERE RERERERDRE RERERERERE
RERERDRDRE REKSLSHGNV EHAPIWRPGA AEQTGGSSSS RPPSLPYGHQ SPMSPRTQDS
LQQRPSVLHN TSSKSLSSSE HSSSSVLRSL PQSSSRYPSY SGHLQRVSVS EAYQAGGLDP
GGAKELSRDS SKSLGRGALS KHQELSSSSS SSKSEPKLAS PGTPGVYPYI PGTHIGRGLP
LLAPENSVGP SGGGGSSSNA PSREKTQNKA MSIQEHELRA LAQQKAFEQH GLYGPPEDRL
SPSQQPPSPA VKGSQRVVTL AQHISVSVCV FYRVKDIWAL FGSKGNNLMT NIFLAAECIE
PVSPAGGMSE PELQGAACPT EQAEQGLGSR SPASSSQPPA FFSKLTENNS AIVKSKKEMI
KKMVVGNENE FNSGQPGTEI FNMPASTTAG PVSVRSHPPP EASGNTIGLE AIIRKALMGK
YDDQADERSP SSSVNQLSAV GTPAAADPRA EEPYSMPGKS KSSSRSNGRK TKSPGPGLSG
GERPSSVSSV HSEGDCNRRT PLTNRVWEDR PSSAGSTPFP CNPFTMQMRL PAPGPSQSQR
PWEEEPKPLL CSQYETLSDS D
//
