ID W5LLD9_ASTMX Unreviewed; 445 AA.
AC W5LLD9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Septin {ECO:0000256|PIRNR:PIRNR006698};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000020651.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000020651.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. Septin GTPase family.
CC {ECO:0000256|PIRNR:PIRNR006698, ECO:0000256|RuleBase:RU004560}.
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DR AlphaFoldDB; W5LLD9; -.
DR Ensembl; ENSAMXT00000020651.2; ENSAMXP00000020651.2; ENSAMXG00000020058.2.
DR eggNOG; KOG2655; Eukaryota.
DR GeneTree; ENSGT00940000157152; -.
DR HOGENOM; CLU_017718_0_1_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000020058; Expressed in camera-type eye and 6 other cell types or tissues.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR CDD; cd01850; CDC_Septin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030379; G_SEPTIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016491; Septin.
DR PANTHER; PTHR18884; SEPTIN; 1.
DR PANTHER; PTHR18884:SF6; SEPTIN-1; 1.
DR Pfam; PF00735; Septin; 1.
DR PIRSF; PIRSF006698; Septin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51719; G_SEPTIN; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU004560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004560};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 110..383
FT /note="Septin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51719"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 58..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 445 AA; 51640 MW; FD22746E74B9F838 CRC64;
MRDLPPRAGH TFPGREMPLM DREPDGSARP HTPGTPTFMR PIGRNLLGSE PELLRRCQLS
STSSLESPLS PSRPRSPWRF DPYDSIEDQD REYVGFATLP NQVHRKSVKK GFAFTLMVAG
ESGLGKSTLI NSLFLTDLYK DRKMLNAEER ITQTVEIIKH TIGIEEKGVK LKLTIVDTPG
FGDAVNNTES WRPIVDFVEQ QFEQYFRDES GLNRKNIQDN RVHCCLYFIS PYGHGLRPID
VEFMKALHEK VNIVPVLAKA DCLTPAELSL KKIKIREEIE RFGIHIYQFP DCDSDEDEEF
KLQDQELKES IPFAVVGSNI LVESKGRRFR GRTYPWGVVE VENPAHSDFL KLRNMLVRTH
MQDLKDVTRE THYENYRAQC IQKMTRMVVK ERKRSLCSHL RESVTDLPLV PVDSETERLI
WEKDEELRRM HEVLERIQEQ MRHGH
//
