ID W5LLY3_ASTMX Unreviewed; 635 AA.
AC W5LLY3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Aryl hydrocarbon receptor nuclear translocator like 2 {ECO:0000313|Ensembl:ENSAMXP00000020845.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000020845.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000020845.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5LLY3; -.
DR STRING; 7994.ENSAMXP00000020845; -.
DR Ensembl; ENSAMXT00000020845.2; ENSAMXP00000020845.2; ENSAMXG00000020233.2.
DR eggNOG; KOG3561; Eukaryota.
DR GeneTree; ENSGT00940000160423; -.
DR HOGENOM; CLU_011864_2_2_1; -.
DR InParanoid; W5LLY3; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000020233; Expressed in embryo and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
DR GO; GO:0009648; P:photoperiodism; IEA:Ensembl.
DR CDD; cd11469; bHLH-PAS_ARNTL2_PASD9; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR23042:SF48; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR23042; CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 93..146
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 165..229
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 365..414
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 635 AA; 69473 MW; 04CC9886C1275BC3 CRC64;
MSASNAAAGG GDRPTGEEAG DALEERLQSH SVSISSLVTP PSAAGMASGM ELPRKRKGST
DNKETKSALM LDEDMQDEQE RSEGDDQHVK IKCFREPHSQ IEKRRRDKMN NLIDELSAMI
PTCNPMSRKL DKLTVLRMAV QHLKSLKGAT SSFAEANYKP SFLPDDELKH LVLRAADGFL
FVVGCDRGKI VFVSESVSKI LNYSRPELIG QSLFDFVHPK DIGKVKEQLS ASELYPRERL
IDAKTGMQVQ ADLPVGAARL CSGARRSFFC RMKYNKVTVK EEKDFQAGSS KKKESQRYCT
VHCTGYMRTW PTSQLGTEGE GESEKDSSHF SCLVAIGRVH PHTVPQANGE VKVKPTEFVT
RCAMDGKFTF VDQRATTILG YLPQELLGTS CYEYFHQDDL PHLADRHRKV LRSKEKIETN
CYKFKTKYGS FVTLQSQWFS FINPWTKEVE YIVSTNTVMS GKNNPGGSGD KSEQPVESKA
SEDDGKKSLP IIPGISNASG TMIYAGSIGT QIANELLDFN RINSSPSSGN ASPFSLLQDK
SPLALTQASS NVPNGEATDV EIPGKSSSED DARSGPFAAG ENPLAEGGSQ LDLEGVPGLG
SLSSDEAAMA VIMSLLETDA NLGEAVDFDE MHWSL
//
