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Database: UniProt
Entry: W5LMN1_ASTMX
LinkDB: W5LMN1_ASTMX
Original site: W5LMN1_ASTMX 
ID   W5LMN1_ASTMX            Unreviewed;       557 AA.
AC   W5LMN1;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   08-MAY-2019, entry version 40.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000021093};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000021093, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000021093, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000021093};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000021093}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000021093};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D.,
RA   O'Quin K.E., Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C.,
RA   Volff J.N., Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000021093}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
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DR   STRING; 7994.ENSAMXP00000021093; -.
DR   Ensembl; ENSAMXT00000021093; ENSAMXP00000021093; ENSAMXG00000020478.
DR   GeneTree; ENSGT00940000156716; -.
DR   OMA; MGMCPTL; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   Gene3D; 4.10.70.10; -; 1.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR018358; Disintegrin_CS.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR034027; Reprolysin_adamalysin.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   PRINTS; PR00289; DISINTEGRIN.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; SSF57552; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS00427; DISINTEGRIN_1; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00068,
KW   ECO:0000256|SAAS:SAAS00877335}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    148    171       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      122    308       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   DOMAIN      316    402       Disintegrin. {ECO:0000259|PROSITE:
FT                                PS50214}.
FT   DISULFID    374    394       {ECO:0000256|PROSITE-ProRule:PRU00068}.
SQ   SEQUENCE   557 AA;  61381 MW;  FAF3AED0B0422B7D CRC64;
     HYTPNGTRVT TLLQDQGEDQ CYYLGSVGDE QQSVVSMSTC DGLRGFFRTG GQDYMIEPLT
     DGEAGDHAVF KAEFLKNKNL LCGVTEKTVE SVLPAFNTKG SRRAVQFDKG NSDRDALMDE
     QKYIEMYLVV DNSEVRSSKN MRKRMFQIIN FVDMVYLPLH TFIALVGLEV WSDRDKINVS
     SSASNTLTAF TQWRINQAKT FKQNDNNFSN TLTIISTLQN HDRWVLVQSE CGDFSSNALA
     TGAVLAHELG HNLGMEHDEP TCSCSSAHCI MSAELSNPPP EKFSNCSVAE YREFLQTTSA
     LTCLLDKPAE GSIIAPPICG NNFKEEGEEC DCGLVEECTN PCCDAATCTL TPGSQCSSGE
     CCNNCKLVPV DSLCRSVMSE CDLPEYCTGA SGDCPADTYR EDGLPCRNNS GYCYHGHCPL
     RQDQCIQMWG DSVVRTRQTI KTCSLTLDTL RSRSVHTVLW LRIVGYVMVR LFCRDVLCGT
     LFCSNGTADP RAGTGVTHDG TCKSTVFNSS MGDELVQPGT KCGDGLVRKS CSLLSQVLSE
     FSHLVKQQIK QLIKQLI
//
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