ID W5LMW2_ASTMX Unreviewed; 944 AA.
AC W5LMW2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=MAM domain containing glycosylphosphatidylinositol anchor 2a {ECO:0000313|Ensembl:ENSAMXP00000021174.2};
GN Name=MDGA2 {ECO:0000313|Ensembl:ENSAMXP00000021174.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000021174.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000021174.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5LMW2; -.
DR STRING; 7994.ENSAMXP00000021174; -.
DR Ensembl; ENSAMXT00000021174.2; ENSAMXP00000021174.2; ENSAMXG00000033842.1.
DR eggNOG; ENOG502QSMD; Eukaryota.
DR GeneTree; ENSGT00940000155369; -.
DR HOGENOM; CLU_014908_0_0_1; -.
DR InParanoid; W5LMW2; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000033842; Expressed in brain and 6 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW.
DR CDD; cd00096; Ig; 2.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000998; MAM_dom.
DR PANTHER; PTHR45080; CONTACTIN 5; 1.
DR PANTHER; PTHR45080:SF23; MAM DOMAIN-CONTAINING GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR PROTEIN 1; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 4.
DR Pfam; PF00629; MAM; 1.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 5.
DR SMART; SM00137; MAM; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50835; IG_LIKE; 6.
DR PROSITE; PS50060; MAM_2; 1.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..944
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017468023"
FT DOMAIN 22..122
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 129..214
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 237..323
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 335..431
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 437..528
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 535..622
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 734..911
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT REGION 764..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 944 AA; 106268 MW; 2659E693F491AC1E CRC64;
VIHIYFLFSF FSFSPPTCEA PPNVRIIHSG HACNVEEDRY TERVYTIREG ETLELVCLVS
GHPRPQIRWT KTAGSASDRF QDSSVFNETL RISRIQRHQG GRYYCKAENG LGSPAIKSFR
VDVYYLDDPV VTVHQSVGEA KEQFYYERTV FLRCAANSNP PVRYSWRRGR EFLSQGSDKG
VEIYEPFFTQ GETKILKLKN LRPQDYANYT CTASVRNVCG IPDKSILFQL SNKTASPTIK
LLVEDPIVAN PGQTVTLVCI TSGGEPTPVL SWVRNAEGLP KKSVLNGGTL TIPAISTEEA
GVYSCVASNN VGNPAKKSTN IIVRALRKGR FWITPDPYHN DDNIQIGREV KISCQVEATP
AEELMFSWLK NGRPLRSSER MVITQTDPDV ALGTTNLDII DLKFTDFGTY TCVASLRNGG
IPEISIDVNI SSTTVPPSLT VPRGKSPLVT QEGDTVELQC LVSGKPKPII LWSHADKELP
MPDGNLQTES YDGILRIVNV SREMTGTYRC QTSQYNGFNV KPREAVVELI VQYPPAVEPV
YTEIRQGLGR AFSLSCRVLR AHPSRVLKYE WKLGTRLLTV GQFDTRDETE YHVRALNREG
YGAYTCDITN EAGAGRCTFL VTGKAFAPEF YYDTYSALWQ NKPSVYGFKL QWTQMNPNSV
DRIMAYRLGI KQTGQQRWWE QEIPMEGNVQ RGDLITYNLT ELVKPEAYQV RLTPITRFGE
GDSAERIIRY SGKFHCNFEE EAICMFTQDK AEEFDWTRHS AATRDTKYTP NTGPSSDRSG
SKQGYYMYIE TSRPRQEGDK ARLLTPLFNV APKNPYGNVA TNPTYCLSFY YHMYGKHIGA
LNVYLRQKSQ TGQDSSVWTL SGNQGDRWRQ ARVNIHPTSS FQMVLEGVRG SGIEGDIAID
DVTIEEGECR DPPPNNLRSL APPTAKHIWQ LCLSVLLASV SHRR
//
