ID W5LP82_ASTMX Unreviewed; 1451 AA.
AC W5LP82;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Nucleoporin 153 {ECO:0000313|Ensembl:ENSAMXP00000021648.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000021648.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000021648.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 7994.ENSAMXP00000021648; -.
DR Ensembl; ENSAMXT00000021648.2; ENSAMXP00000021648.2; ENSAMXG00000021025.2.
DR eggNOG; KOG4719; Eukaryota.
DR GeneTree; ENSGT00940000153253; -.
DR HOGENOM; CLU_004629_1_0_1; -.
DR InParanoid; W5LP82; -.
DR OrthoDB; 2920135at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000021025; Expressed in camera-type eye and 14 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 3.
DR InterPro; IPR026054; Nucleoporin.
DR InterPro; IPR013913; Nup153_N.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR23193; NUCLEAR PORE COMPLEX PROTEIN NUP; 1.
DR PANTHER; PTHR23193:SF23; NUCLEAR PORE COMPLEX PROTEIN NUP153; 1.
DR Pfam; PF08604; Nup153; 1.
DR Pfam; PF00641; zf-RanBP; 3.
DR SMART; SM00547; ZnF_RBZ; 3.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 3.
DR PROSITE; PS01358; ZF_RANBP2_1; 3.
DR PROSITE; PS50199; ZF_RANBP2_2; 3.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT DOMAIN 668..697
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 745..774
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 806..835
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 68..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 848..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 948..968
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 986..1051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1109..1196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1213..1243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1300..1356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1379..1398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1423..1451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..460
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..632
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1018
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1033..1048
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1163..1196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1300..1332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1340..1356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1423..1441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1451 AA; 147424 MW; EA1AAF7F7E7B3EBC CRC64;
MAATGGGKIR TRRYHIASKP YAKGKQQQPG LISRVTDTVK SIVPSWLQKY FKNGELTAGE
EARVDVEQNN VAPPPNGNED PAPLQDGRNS PEPSTSNAEP STSKASLNFQ DVLSRPPLNR
SHLQFPTQDG SPSLGVSNFL FSQPSTSTAS FAASPFAVAS NFSLVKEIKD SSSQHEDDNI
STTSGFSSRA SDKDVPTSKT APLLWSPETD RTHSGSQSGQ TGLKKPAFNL SVFGTSSSSV
MNNSVLNSSQ LGDSPFYPGK TTYGGAAAAR SGRARPGTPY HAPVRRQIKA KPAGAQPCGV
TSATARRILQ SLERMSSPLA DAKRIPSTVS SPLSTSLNHS DLDVSSFQSK KKKVEPALPP
VQKLVIPAAA SVASNRSMSF RPSLTPGSVS RVVDKSNKET PVRRSPKRPD APAPPPSTSG
LSYPLSSTPT TSNTGAGGGK MKRERSIRPS SKKTDDEVSE APDLPAISLP LSNSPLPTFS
FSSPPPTSTL KPNNKPSTLI PKEPAISKQA PTVPTTPDAP FTFSTPIVKA TAASPPSFSP
STGFTFSAPT MKTTPSASNG KPAPAAVAVK PAARECKEEF EGPFKPAKVL KQGSVLDILK
GPGFASPAAG PPVPELRSAS ESSSSAGSKF KPSLGTWNCE PNKESSSKSD SKPAKAPAAS
LNTLFARPPG TWDCDTCLVQ NKPEVFKCVA CDTAKPGTGV KPTLTLPPVL ETPSTVSASS
SSTTTSTSSC TTSGLLGFGD KFKKPEGAWE CDVCMVQNKA QDSKCVACQT AKPGSASAAP
SSLAPAAPKP ASTAPLLGFG DKFKKPEGSW DCDVCCVQNK SGDQQCVACQ SPKPGAKVES
KGFVSSFGTQ SSSTDSSSSA FKFGTGSSNS TSVGLKFGGS FTNSSNSLDF KMGNTSDSNS
SSGGFKFGAS SADSTGGFKF GGASDSTSTS TSSSEGFKFG GSSDGFKFGA TPASTNTENK
NDSTNSSTGF KFGGGSGVTF GSTAASTSTT VTGGFSFEQP KPKDQLVNTA NSSLEFDSSA
PKAKAEKDDP PFTGGSASST SASSTIPVFG KPTVAEPKTA TLSFGEPAAK EPALATSTFT
FGKPEEKKDA ALPSSGFVFN AAKEADKPAP SLGFSFSKPE PPKEVPKPAF TFGKPAESTE
APKPPTFGFG QSAADTATPK PAFGFMVNSS STPASSSPAP SIFGAQSSSS TLAPTSAPTS
TFMFGQSASS DAPPAKAFMF GQQDSQPASA APPAPAAAAA PAPAPAQPFL FGSTANSTDF
SFGGAATATP ASAAPAPSAA PSPFVFSSAT VSTGFGSGQA PAFGQGSSQP AAPAFGSPAP
SFSATNSASP AFGAKPNAAP SFGQQPNATP VFGSSAPSAG QGGFQFGGAS AFGTPNRNSA
VFTFGGGAGN AANSAPSPVM SAQPVAAGGG FGFSQPPAFN IGSTKSVSSA TPATQHTISG
RKIKTAVRRR K
//
