ID W5LPY2_ASTMX Unreviewed; 771 AA.
AC W5LPY2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Kelch-like family member 11 {ECO:0000313|Ensembl:ENSAMXP00000022012.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000022012.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000022012.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR AlphaFoldDB; W5LPY2; -.
DR STRING; 7994.ENSAMXP00000022012; -.
DR Ensembl; ENSAMXT00000022012.2; ENSAMXP00000022012.2; ENSAMXG00000021378.2.
DR eggNOG; KOG1072; Eukaryota.
DR GeneTree; ENSGT00940000159275; -.
DR HOGENOM; CLU_024322_0_0_1; -.
DR InParanoid; W5LPY2; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000021378; Expressed in brain and 13 other cell types or tissues.
DR CDD; cd18451; BACK_KLHL11; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412:SF35; ACTIN-BINDING PROTEIN IPP; 1.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 2.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 4.
DR SUPFAM; SSF50965; Galactose oxidase, central domain; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 130..231
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 57..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 771 AA; 85906 MW; 01FA83B8F59E17D5 CRC64;
MRCNGTGSPC LCLCRCVCAR GAVRGCAGRC MLVCVCLSLL YRTGLLRFLR FQPTEGGMAA
AAPNPEEPSR SGAGGGVGAG GAGGGGGGGG SAASLSGDGE SEEAEEFSSA THCSELSRRQ
NEQRKLGLFC DVTLVFSGGG AAGASAAALA AGEHLSGVGG ALTHHSFELC AHRSVLAAAT
DYFTPLLGGQ FSESVSRRVE MKEWSSEAGP DRDTVESVVQ FMYTGEIRVS TANVHEVLEL
ADRFLLVQLK EFCGEFLKRK LSLANCVAVH SLAHMYTLDQ LALRAADMIR RNFHKVIQDE
EFYTLPFHLV RDWLSDAEIT VDSEEVLFDA VVKWVQKNSE EREKYFEELF RLLRLPQIKP
TYLTRVVKNE PLVAQNAACL QLVSDAVEGH AIRFENLKSA DTEFWASYMA AFQPRFGQNM
DVIMVVGGVS EGGDYLSECV GYFVYEDRWV NLPHIHNHLD GHAIAATDSH VYVAGSMEPG
FAKTVERYNP NRNTWEQVSN LTTRKHSFGL TCIKNILYSI GGHGNFSPGF KDVSVYEPEQ
DKWHNLESAP KILRDVKAIS VEDRYVYVTA RTPVDTDNDD GLKTVTTRYD TDSRQWQEVD
SLPLIDNYCL FQMAVASTNF YHTASCCPRS YAAIRDEVAR QKISARISDD ILESLPPEVT
SIEGAAICYL GDDVFVIGGW KNSDDVDKQY RKEAYRYCAE RKRWMLLPPM PQPRCRATAC
HVRIPYRFLY GCQRYPMPQN LARQRDRMQQ MQQLHRRTLT LRRQLQSQIE C
//
