ID W5LPY8_ASTMX Unreviewed; 1011 AA.
AC W5LPY8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=B30.2/SPRY domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000022019.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000022019.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5LPY8; -.
DR Ensembl; ENSAMXT00000022019.2; ENSAMXP00000022019.2; ENSAMXG00000021381.2.
DR eggNOG; ENOG502SBIG; Eukaryota.
DR GeneTree; ENSGT01100000263476; -.
DR HOGENOM; CLU_002274_0_1_1; -.
DR InParanoid; W5LPY8; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000021381; Expressed in zone of skin and 3 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd16040; SPRY_PRY_SNTX; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 3.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 199..333
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 815..1011
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
SQ SEQUENCE 1011 AA; 114723 MW; 55F393352C49CE5D CRC64;
MHYTCNNVNI THLRASITQC PGQISVSVMF YILISNFLMY VLNQELQQKF ISLVKNELNT
FKKLLSRDCP ACLEGEVEDE DRREGVLEIT LHILRSMRQT DLANKLQSKL APACHHKLKS
KLKEKCQRIN EGISGHGNSS LLNEIYTELN ITEGRVGEVN RGHEVRKIED ASRKMASQER
PVKCNDVFKP LPEENQPIKT VLTKGVAGIG KTVSVQKFIL DWAEGKANQD VHFIFPLPFR
ELNLMKEKKL SLVSLLQFFF PETTDLKPRH YKYHKIMFIF DGLDEYRMPL DFQNHESLVD
IEEQATVDVL LTNLIRGNLL PSALLWITSL PAAVSQIPPK YVDLVTEVRG FNDPQKEEYF
KKRICDQNLA NKVITHIKSS RSLHIMCHIP VFCRIAATVL EIMLSEAESG EIPKTLTKMF
ARFLVFQIKC KSQKYSGKSD LDFDQTRKSI LALGKLAFKQ LEKGNLIFYE EDLKESGIDI
KEVSVYSGVF TQIFREDNEL HLGKVFSFVH LSIQEFLAAL YAFIKRKVLN QQTNKHFRIS
KPPMTNFLNS AVDRALQTEG GQLDLFLRFL LGLSLETNWT PLRGILTPTE RSSHSNEETV
TYIKKKIKKS ICPEEPIRLF HCLNELNDHS LVQEVQKYLC RDGDHHRRAS LSSVHCSALA
FVLMNSEEEL DEFNLSKYDS SERCLPRLLP VVEASKKAVL ASCNLGENVC EILGSVLNRE
NSSLKELDLS NNDLQDSGVK LLSAGLKSSH CKLQILRLSG CMVTKKGCSF LAEALTSNPS
HLEELDLTYN NPEISGVKLL SAKLEDPHCK LKTLRAEHGG GIRIKPGLKK YGCDLTLDPN
TAHTQLCLTE KNRKVVGGEE QSYPDHPDRF NAYHQVMSRE SLTGRCYWET EWSGDLWGAD
IGLTYKTISR KGLNEDCGFG WNENSWILIC FKNRYSVQHN KDITTVASRP PSSRRVGVYV
DCPAGTLSFY SVSSDTHTLT HLHTFNTTFT EPLHAAFRVG EGSSLCVCKM E
//
