ID W5LQF3_ASTMX Unreviewed; 820 AA.
AC W5LQF3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Ras GTPase-activating protein 2 {ECO:0000313|Ensembl:ENSAMXP00000022250.2};
GN Name=RASA2 {ECO:0000313|Ensembl:ENSAMXP00000022250.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000022250.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000022250.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 7994.ENSAMXP00000022250; -.
DR Ensembl; ENSAMXT00000022250.2; ENSAMXP00000022250.2; ENSAMXG00000021592.2.
DR Ensembl; ENSAMXT00000053491.1; ENSAMXP00000053593.1; ENSAMXG00000021592.2.
DR eggNOG; KOG2059; Eukaryota.
DR GeneTree; ENSGT00940000158201; -.
DR HOGENOM; CLU_008096_1_1_1; -.
DR OrthoDB; 24454at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000021592; Expressed in pharyngeal gill and 14 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd04010; C2B_RasA3; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR10194:SF21; RAS GTPASE-ACTIVATING PROTEIN 2; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00779; BTK; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00107; BTK; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00432}.
FT DOMAIN 1..112
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 123..263
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 329..523
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 578..679
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 820 AA; 93141 MW; 7BB67B3F95F45D47 CRC64;
MEEPRIRVLQ SLRGKICEGK NLGCGSGSNR LRDVGTFCTI SLDQEEVFRT KVYEKSLSPF
YGEDFYFEIP RPFQCLSFHV YAKSVFQREQ PVGKVSIRKD DLSKYSGKEH WFGLQPVDPN
SEVQGKVHLE MKLNELITDN GPVSPRLQVR IIECQGLPLI SGQNCDSFAS VTLIGPSRSD
QRKTKVKKKT SDPHFDETFY FEVSRSSSYT KKSHFQVEEE DIEKLEIKVE LWNNGNLAQD
VFLGETRVSL KILRNDLVHK AWYLLQPRGN GTKPKPDDLG SLRLNVNYTE DNVLPSPCYV
PLRKLLLRSP DVKPVSASAA HILGDVCRDR YEASLPVVRL LLHHNKLLPF LTAISALELE
NTQEANTIFR GNSLATRCID DMMKMVGRSY LTITLKTVLD EICDSNKSCE IDPIKLKEGD
NVEVNKENLQ IYVQKVFSSI TQSSASCPPL MCDVFRALRR LASDRFPGDP HVQYSAVSSF
VFLRFFAVAV LSPHTFQLRP HHPDPEVCRT LTLISKTIQT LGSWSSLSKN KLSSFKETYM
YDFFKLFQED QCIEKVKKFL DDISSNVSKG TCGVEDSVVL KEGEIHKRAQ GKKLLGKKNF
KKRWLRITTR ELSYHKHKGK DALCVIPVKN ILGVEKLEEN AFNRKNMFQV LLGERPLYVQ
AGNCVEASEW IEVLSQVSRC NPGRLSTFHP SAFVGGVWLC CKETTENLPG CRPCTTSTLA
NIQLEIDCDR ETERIFSLFS ASLPRLQKME DACAGMSVYL GQQKEQEEYS AFIIQDPKET
FRTIKEIREV LEELKAQHTD KEALTDQPGT IENPIVGKVL
//
