ID W5LR43_ASTMX Unreviewed; 741 AA.
AC W5LR43; W5LR42;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Ral guanine nucleotide dissociation stimulator-like 2 {ECO:0000313|Ensembl:ENSAMXP00000025317.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000025317.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000025317.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 7994.ENSAMXP00000025317; -.
DR Ensembl; ENSAMXT00000025334.2; ENSAMXP00000025316.2; ENSAMXG00000024613.2.
DR Ensembl; ENSAMXT00000025335.2; ENSAMXP00000025317.2; ENSAMXG00000024613.2.
DR eggNOG; KOG3629; Eukaryota.
DR GeneTree; ENSGT00940000167370; -.
DR HOGENOM; CLU_010252_0_1_1; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000024613; Expressed in olfactory epithelium and 14 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd17211; RA_RGL2; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF350; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 2 ISOFORM X1; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 103..226
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 261..519
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 623..709
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 37..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 741 AA; 82534 MW; 77D043A08640000F CRC64;
MLPRSMRTAG VDLPGVGSKD VPLIGYRPLQ PEANQFQLTD QTGKGAGTRD QDTSQVEASP
MKTTWYCPLN LSTVSEKEED GIVYTVVVKP PHGSSHPQSV GQRSQCVKAG TEEKLVLHLL
HSFSMEDSSF ITIFLSTYRS FTTTQRVLDI LTDRLGNPPG ENNSATRQAF NKAVCTVFST
WLSEYPEDFR SLGDPSRLLR LAPLLPTDAA GADLKGRLLR IAEELSEKAL IPDQPPDSAN
TFLQNPPDPK KFEATSILGF PSSVIAEQLT KIETELFLKL VPYHCLGSLW SQRDKKGREG
VCWSVRATVR QFNRLANAVT ASCLWQTELK TQQRSRFLEK WISVAEACRA RKNFSSLYAI
VSALQSNPIH RLRKTWQETD REAVKRYEEL AYIFSEKDNY SQSRELLKEE GTSKTANVDT
KINNRRHTSS AQGTVPYLGI FLTDLTMLDA AVKDRLENGY INFDKRRREF EVLAKIRLLQ
SSCRNSTFRS DESFLHWYHS VPMLTEEESY RLSNQIESHG DPSPGRALHP TVVITECPDA
LSTVTSVDAD GIFDFPSPVN HLLSKLAKHM KSPSVSCLDV DSSPPPNDPT PSALTTPTVV
KSHRRSVSCG NAPSTASPGA GPDMRIVRIR MELHDGNLYR SILVTSNDKT PTVISSALEK
HNQDPREASK YELIQLLPDG KELTIPATGN VFYAMTSASM DFLLRRRGGN TPVGSPSLNN
ETSATFPRIK AKGRRLVRTL F
//
