ID W5LR59_ASTMX Unreviewed; 301 AA.
AC W5LR59;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=1-phosphatidylinositol phosphodiesterase-like {ECO:0000313|Ensembl:ENSAMXP00000025333.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000025333.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000025333.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; W5LR59; -.
DR STRING; 7994.ENSAMXP00000025333; -.
DR Ensembl; ENSAMXT00000025351.2; ENSAMXP00000025333.2; ENSAMXG00000024628.2.
DR eggNOG; KOG4306; Eukaryota.
DR GeneTree; ENSGT00390000010118; -.
DR HOGENOM; CLU_024117_3_0_1; -.
DR InParanoid; W5LR59; -.
DR OrthoDB; 5490382at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000024628; Expressed in ovary and 1 other cell type or tissue.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd08586; PI-PLCc_BcPLC_like; 1.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR PANTHER; PTHR13593:SF148; SI:DKEY-152B24.6-RELATED; 1.
DR PANTHER; PTHR13593; UNCHARACTERIZED; 1.
DR Pfam; PF00388; PI-PLC-X; 1.
DR SMART; SM00148; PLCXc; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..301
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017362312"
FT DOMAIN 55..185
FT /note="Phosphatidylinositol-specific phospholipase C X"
FT /evidence="ECO:0000259|SMART:SM00148"
SQ SEQUENCE 301 AA; 33777 MW; 11FB4F532F29C86A CRC64;
MKNFNQVLGV SLLIVLLGKS LGQSQNQAFN DAEKLQLPQS YQINWMSNLN DNFYLSQLTL
PGTHDTMARY GGPAVDCQVW TLEDQLKAGI RYLDLRAFAF GDSLRLMHGI VYEFSTFKEA
LATIKKFLSQ YPTETVLVRV KPELLNKENV QGLVEQAIYN DQNVWVSSTV PTLGQVRGKV
VFVQKDSFKL GLPLVETDTK GDYEVTHIKQ KEQEVSSHLN QALTKCGGSS IILTYSSGTG
IGTFEGMFLT PKRVAEKIDP WLYSYLEVYL NNVPDICFGI IAMDFPGLEL IQAVINFNLQ
L
//
