ID W5LT88_ASTMX Unreviewed; 823 AA.
AC W5LT88;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000026299.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000026299.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5LT88; -.
DR Ensembl; ENSAMXT00000026320.2; ENSAMXP00000026299.2; ENSAMXG00000025595.2.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000164468; -.
DR HOGENOM; CLU_006480_3_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000025595; Expressed in brain and 2 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF342; PROTOCADHERIN GAMMA-B1; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..823
FT /note="Cadherin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017332565"
FT TRANSMEM 677..702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..122
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 123..231
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 232..336
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 345..441
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 442..552
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 567..664
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 823 AA; 91044 MW; D25D10585F0E547F CRC64;
VTYHVCVLQF LSAHSALGQV SYSIPEEMSK GSMVGNIVQD LGLDLKRLQS GKARIFTEDS
TEYIELNKER GVLLIKEKID RESLCAKTTP CALHIQVILE NPMELYYITV EVTDINDNAP
LFQTEEISFE ISESAVTGAR FTLERAIDVD VGANELKSYL LKPTDHFVLD LQNQAGGDKR
VQMVLQKPLD REKQERFTLL LTANDGGEPV LSGSVKIHVT VLDANDNAPV FTQNVYKATL
FENASKGTKL TIVSASDADE GSNGHIMYYM SKTLDSLSDM FIVDEYSGDV FLNGQVDFEK
SSIYELEIQA KDHGGLSDTC KLVIDVLDIN DNRPSINIIS KSNYISEDSK PGTTIVMMKV
NDPDSGINGK VHCTISENIP FSITSPSNNF FSLRTDQELD RESNNEYNIT VVCSDEGLPS
LSSSASLYLT ISDVNDNAPV FERSSYEAFV LENNTPGHSI FTVKARDADL NQNARVSYIL
EDSTINGVRV SSYVVSVSAD SGVINAVRSF DYEQLKDFHF RVIAQDGGSP PLSSNVTVTI
TIQDQNDNAP QVLYPVQTGG SLVAEIVPRS ADVGYLVTKV VAVDVDSGQN AWLTYKLQKA
TDRALFEVGP QNGEIRTVRQ VTDKDAVKQK LTVVVEDNGQ PSRSAVVNIN VAVADSFPEV
LSEFTDLTHG KEYNDNLTFY LVLALAAVSF LFITCVVVII SVKIYRWRQS RVFYQSNLPV
IPYYPPGYTD TGVTGTLPHM YNYDVCMTTN SRKSDCKYST LGGHSVLMVD PSFSETMQRE
MRDKCLLEDH NSPELVSYFL CYVINILNIS NYAACHEGKF LAG
//
