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Database: UniProt
Entry: W5LTJ2_ASTMX
LinkDB: W5LTJ2_ASTMX
Original site: W5LTJ2_ASTMX 
ID   W5LTJ2_ASTMX            Unreviewed;       437 AA.
AC   W5LTJ2;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   16-OCT-2019, entry version 36.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000026454};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000026454, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000026454, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000026454};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000026454}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000026454};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D.,
RA   O'Quin K.E., Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C.,
RA   Volff J.N., Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000026454}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   RefSeq; XP_007237384.1; XM_007237322.2.
DR   STRING; 7994.ENSAMXP00000026454; -.
DR   Ensembl; ENSAMXT00000026475; ENSAMXP00000026454; ENSAMXG00000025749.
DR   GeneID; 103030516; -.
DR   KEGG; amex:103030516; -.
DR   GeneTree; ENSGT00960000186595; -.
DR   KO; K04996; -.
DR   OMA; VFSHYAT; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003271; K_chnl_inward-rec_Kir2.1.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR013673; K_chnl_inward-rec_Kir_N.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF43; PTHR11767:SF43; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   Pfam; PF08466; IRK_N; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     85    109       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    156    181       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1     49       IRK_N. {ECO:0000259|Pfam:PF08466}.
FT   DOMAIN       50    186       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      193    365       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      387    437       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    410    424       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   SITE        172    172       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   437 AA;  49692 MW;  A5354327E46E10A6 CRC64;
     MGSVRAHRYS IVSSEEDGMK LATIGVPNGY GNGNAGGKVH THHQTQCRFV DKDGHCNVQF
     INMSEKGQRY LADIFTTCVD IRWRWMLVIF CLSFLLSWLL FGFVFWLIAL ANGDLVNEEQ
     ICVSNVDSFT AAFLFSVETQ TTIGYGYRYI TEDCPVAVFM VVFQSIFGCI IDAFIIGAVM
     AKMAKPKKRN ETLVFSHYAT IAMRDTKLCL MWRVGNLRKS HLVEAHVRAQ LLKSRTTVEG
     EYIPLDQMDI DVGFDTGIDR IFLVSPITIV HEIDEDSPFY DMSKQELENS EFEIVVILEG
     MVEATAMTTQ CRSSYIASEI LWGHRFETVL SEEKNLYMVD YAKFENTYEV PSTPQCSARD
     LAEKKYILTA SNSFCYENEI ALMDKEDIDE DEEHEDVKND LFGERAEGTN TDLISESASS
     QETVLLEARP LRRESEI
//
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