ID W5LUA1_ASTMX Unreviewed; 882 AA.
AC W5LUA1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Toll like receptor 5 {ECO:0000313|Ensembl:ENSAMXP00000026717.2};
GN Name=TLR5 {ECO:0000313|Ensembl:ENSAMXP00000026717.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000026717.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000026717.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR AlphaFoldDB; W5LUA1; -.
DR STRING; 7994.ENSAMXP00000026717; -.
DR Ensembl; ENSAMXT00000026738.2; ENSAMXP00000026717.2; ENSAMXG00000026012.2.
DR eggNOG; KOG4641; Eukaryota.
DR GeneTree; ENSGT00940000162464; -.
DR HOGENOM; CLU_006000_4_0_1; -.
DR InParanoid; W5LUA1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000026012; Expressed in mesonephros and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR026906; LRR_5.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF525; TOLL-LIKE RECEPTOR 5; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13306; LRR_5; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 5.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 7.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 12.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 6.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..882
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030179489"
FT TRANSMEM 656..679
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 709..854
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 882 AA; 101446 MW; A5909C5391284D66 CRC64;
MARRVILSIL LLEFYTCLHM ANCFSPCLIY GTTANCYDRR LYQVPPLPNH ITYLNLANNY
ISELTEASFL GLGALEVLNL QQQETQLVLK NNTFARLSNL LELNLGFNHF LQMETNAFSG
LHNLQILNLI QCNLKDSVLS GDYMKPLVSL ESLTLETNDI KRVQPARSFL NMTKLHQLDL
SHNWINSICE EDFTGFQGKH FTIFKLTNIK LSDMSQYWSK WDQCGNPFKD MSINILDLSH
NSFSVDMARL FFRAIRGTQI DTLILSHSSS MGKSVGNNNL KDPDQQTFKD LAASGIKEFD
LSKCRIFALT HSLFHNLPDL QAVSLASNSI NQIESNAFLG VPYLRLLNLS SNLLDKIESR
TFSNLPNLEF LDLSYNNLRI LTQESFSGLP NLLSLDLTDN SLQDLYKMAQ LPQLKELYLA
NNKIKSLYGL SNIARNVSVL HLANNKLTNA EDIYYILEEF PDITGLSVEG NVFIWCYLNR
KYSVSPLNKL QLLNLRMTGL QNIWAQGLCL DVFDNLRQLQ YLFLQNNYMQ TLPKGIFKGL
TSLHFLNLST NSLTYIPNGT FPASLRTLDL AYNHLGSIDP QALSNITEIS LYKNSFLCDC
GLRRFQKWLN ETSTEFITPV EDLICEFPEE QRGVPLVYSV FCEDLEDEES DEILRLTLFI
CCTTFILLII ICAVVFIRLR GYCFKLYRRM VIKFVEGRPP GKEPGDDGFL YDVYLCFSSN
DFKWVEKALL KKLDSEFSEH NQFRCCFEAR DFLPGEDHLS NMRNAVWNSK KVLCVVSREF
LKNGWCLEAF TLAQSKMLEE VQDILLMLLV DQIPQYRLMK YEPIRTYVQT KRYLCWPEDS
QDLQWFYNQL QHSILKGTKA KQAKIDAETA NNVPEVEAVT VF
//
