ID W5LV31_ASTMX Unreviewed; 569 AA.
AC W5LV31;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Leucine-rich repeat transmembrane neuronal protein 4-like {ECO:0000313|Ensembl:ENSAMXP00000027206.2};
GN Name=LRRTM4 {ECO:0000313|Ensembl:ENSAMXP00000027206.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000027206.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000027206.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5LV31; -.
DR STRING; 7994.ENSAMXP00000027206; -.
DR Ensembl; ENSAMXT00000027227.2; ENSAMXP00000027206.2; ENSAMXG00000026501.2.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000154909; -.
DR HOGENOM; CLU_032965_0_0_1; -.
DR InParanoid; W5LV31; -.
DR OrthoDB; 5344967at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000026501; Expressed in brain and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24373:SF283; LEUCINE-RICH REPEAT TRANSMEMBRANE NEURONAL PROTEIN 4; 1.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR Pfam; PF13855; LRR_8; 3.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00369; LRR_TYP; 9.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 2.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..569
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017253424"
FT TRANSMEM 454..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 380..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..412
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 569 AA; 63986 MW; EB027587DE201E3B CRC64;
MGSMVCTRRL ACLLLLLAST LLLLCSGEKT CPYNCRCEGK IVHCDSASFM DVPENISVTC
QGLSLRNNDL HTMLPYQFAH LNQLLWLYLD HNQISFVDSR AFQGIRRLKE LILSTNRISQ
LHNATFHGVP NLRSLDLSYN KLQELQPGQF HGLRKLQNLH LRSNGLTTIP IRAFIECRSL
EFLDLGYNRL RILTRTAFLG LSRLMELHLE HNQFSRINLF LFPRLANLRG LYLQWNRIRA
VNQGLPWIWY TLQKLDLSGN EIQSLDPVVF QCLPNLQVLN LESNKLANVS HETVASWISL
TTISLAGNVW DCGPGICPLV AWLRNFRGTK DTSIICSSPK HLQGEKVMEA TKNYIDCEDF
ELIPQTPFPH YTLEPTMEVT SMPPLPPTTP LPPLPPPASE APIPPPLSQP IPRPTLRSLA
GTGRRNTPPQ TTPPTDSLLV TSSPEQENLA FHKVVVGAVV LFFSTSLILT VIYVSCRRYP
GATRLLQQRS VMGRKRRKKS PEPEQNLSSQ LQEYYMSYNP AATPEAMDVL ANGTGTCTCT
ISGSRECENE YTCPRPLPGA WIGDIPTIH
//
