ID W5LW42_LEPOC Unreviewed; 505 AA.
AC W5LW42;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Zinc finger and BTB domain containing 8B {ECO:0000313|Ensembl:ENSLOCP00000000349.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000000349.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000000349.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5LW42; -.
DR STRING; 7918.ENSLOCP00000000349; -.
DR Ensembl; ENSLOCT00000000349.1; ENSLOCP00000000349.1; ENSLOCG00000000323.1.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000154994; -.
DR HOGENOM; CLU_022356_0_1_1; -.
DR InParanoid; W5LW42; -.
DR OMA; MMDVQTD; -.
DR Proteomes; UP000018468; Unassembled WGS sequence.
DR Bgee; ENSLOCG00000000323; Expressed in brain and 11 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 2.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR46105; AGAP004733-PA; 1.
DR PANTHER; PTHR46105:SF24; ZGC:110075 PROTEIN; 1.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 24..93
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT DOMAIN 356..383
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 384..412
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 128..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..499
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 505 AA; 55719 MW; FE8447C45CE06107 CRC64;
MEVPSYQAKL LCELNEQRKR DFFCDCSVIV EGRLFKAHRN VLFASSGYFR ALLVHYLQDS
GQRHSTASLD IVTSEAFSLI LDFLYSGRLD LRSDNVIEVM SAASYLQMTD VVNFCKAYIR
SSLEICNRER ERERERERER EREDQADSGS PAGAAAASTS LGDCTHSSPD EPSSQALPGP
LPAPVPHSRD SESESSRGEF PSFHPVDLAL KAPPAGKVNS SSSYLLGLVH PKTEFDPDEE
GEGPTGGKYT PLFHAPPADD DRPHPSSQPA GSESSPLPYD NYHMKQFLEV LLRGGSNPRR
EELVQHFAQS LGGGVGVGRG ATEESLGLGT PSIMEIHSDW YGDDTGYGLV VPVKLHKCPF
CPYTAKQKGI LKRHIRCHTG ERPYPCETCG KRFTRQEHLR SHALSVHRSN WPIVCKGCRR
TFTGVISHGL KRFGLCDGCT CVTTTHEDAA PINLSSQSEG PERSDGDGDW PIYMEEAEEG
EPGGGEDLDD KHELHRQLSE SEGLM
//
