ID W5LWP6_LEPOC Unreviewed; 324 AA.
AC W5LWP6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Ectonucleotide pyrophosphatase/phosphodiesterase 2 {ECO:0000313|Ensembl:ENSLOCP00000000553.1};
GN Name=ENPP2 {ECO:0000313|Ensembl:ENSLOCP00000000553.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000000553.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000000553.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5LWP6; -.
DR STRING; 7918.ENSLOCP00000000553; -.
DR Ensembl; ENSLOCT00000000554.1; ENSLOCP00000000553.1; ENSLOCG00000000503.1.
DR eggNOG; KOG2645; Eukaryota.
DR GeneTree; ENSGT00940000155778; -.
DR HOGENOM; CLU_063241_0_0_1; -.
DR InParanoid; W5LWP6; -.
DR OMA; MEVADEP; -.
DR Proteomes; UP000018468; Unassembled WGS sequence.
DR Bgee; ENSLOCG00000000503; Expressed in liver and 13 other cell types or tissues.
DR GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd16018; Enpp; 1.
DR Gene3D; 4.10.410.20; -; 2.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR020436; SMB_chordata.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR PANTHER; PTHR10151; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE; 1.
DR PANTHER; PTHR10151:SF21; ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 2; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR Pfam; PF01033; Somatomedin_B; 2.
DR PRINTS; PR00022; SOMATOMEDINB.
DR SMART; SM00201; SO; 2.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR SUPFAM; SSF90188; Somatomedin B domain; 2.
DR PROSITE; PS00524; SMB_1; 1.
DR PROSITE; PS50958; SMB_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..324
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004867240"
FT DOMAIN 55..98
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT DOMAIN 99..143
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT REGION 36..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 324 AA; 36684 MW; C55474403074A404 CRC64;
CNRFFSFSFP QVLCVFSLVL GANVGLGYVY SRQRRSGEWD EGPPDPESNS PWVSTSGSCK
GRCFELQEAE PPGCRCDNLC KTYNSCCTDF DDLCLRTAQG FECSKERCGE TRNEENACHC
SEDCLAKGDC CTNYKALCKG ETPWVQDECE EIKTPECPAG FVRPPLILVS VDGFRASYMK
KGNTVIPNID KLRTCGTHAP YMRPMYPTKT YPNLYTLATG LYPESHGIIG NSMHDPVFDA
NFNFRGREKL NHRWWGGQPI WITSVKQGVK AGTFFWPVVI PLERRVLTIL HWLHLPDNER
PYVYAFHSEQ PDIFGHRLGP LSSE
//
