ID W5LWS2_LEPOC Unreviewed; 199 AA.
AC W5LWS2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Endothelin 4 {ECO:0000313|EMBL:ALD51557.1};
DE SubName: Full=Endothelin-1-like {ECO:0000313|Ensembl:ENSLOCP00000000579.1};
GN Name=EDN4 {ECO:0000313|EMBL:ALD51557.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000000579.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ALD51557.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26337547; DOI=10.1093/molbev/msv179;
RA Yun S., Furlong M., Sim M., Cho M., Park S., Cho E.B., Reyes-Alcaraz A.,
RA Hwang J.I., Kim J., Seong J.Y.;
RT "Prevertebrate Local Gene Duplication Facilitated Expansion of the
RT Neuropeptide GPCR Superfamily.";
RL Mol. Biol. Evol. 32:2803-2817(2015).
RN [3] {ECO:0000313|Ensembl:ENSLOCP00000000579.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
CC {ECO:0000256|ARBA:ARBA00010959}.
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DR EMBL; KT235774; ALD51557.1; -; mRNA.
DR RefSeq; XP_015194615.1; XM_015339129.1.
DR STRING; 7918.ENSLOCP00000000579; -.
DR Ensembl; ENSLOCT00000000580.1; ENSLOCP00000000579.1; ENSLOCG00000000527.1.
DR GeneID; 107075948; -.
DR KEGG; loc:107075948; -.
DR eggNOG; ENOG502SSRI; Eukaryota.
DR GeneTree; ENSGT00950000183053; -.
DR HOGENOM; CLU_090013_4_0_1; -.
DR OrthoDB; 4265288at2759; -.
DR Proteomes; UP000018468; Unassembled WGS sequence.
DR Bgee; ENSLOCG00000000527; Expressed in zone of skin and 2 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0031708; F:endothelin B receptor binding; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IBA:GO_Central.
DR GO; GO:0003100; P:regulation of systemic arterial blood pressure by endothelin; IBA:GO_Central.
DR GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR GO; GO:0014826; P:vein smooth muscle contraction; IBA:GO_Central.
DR InterPro; IPR020475; Endothelin.
DR InterPro; IPR019764; Endothelin_toxin_CS.
DR InterPro; IPR001928; Endothln-like_toxin.
DR PANTHER; PTHR13874; ENDOTHELIN; 1.
DR PANTHER; PTHR13874:SF12; ENDOTHELIN-3A; 1.
DR Pfam; PF00322; Endothelin; 1.
DR PRINTS; PR00365; ENDOTHELIN.
DR SMART; SM00272; END; 2.
DR PROSITE; PS00270; ENDOTHELIN; 2.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Vasoactive {ECO:0000256|ARBA:ARBA00022858};
KW Vasoconstrictor {ECO:0000256|ARBA:ARBA00023322}.
FT TRANSMEM 31..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 88..109
FT /note="Endothelin-like toxin"
FT /evidence="ECO:0000259|SMART:SM00272"
FT DOMAIN 134..155
FT /note="Endothelin-like toxin"
FT /evidence="ECO:0000259|SMART:SM00272"
FT REGION 180..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 199 AA; 22692 MW; 82AD621BFDA391B3 CRC64;
MLHSLVCATG YTVTACCLRR FLCNTCTFLN LFIFVSQMDI ISFYFFSSTL VLFLEQKAYS
TSPGASLLGS ESDPETKPTH KALHREKRCS CVNLKDKECV YFCHIGIVWV NTPGQVVPYG
VGYYPVRLRR ETARCLCVSN SDVQCRRFCT KKYLLQEHTA HVLLNKSLFA KKMEIVERKH
RPDSPSVKTG KLEISIQNT
//
