ID W5LXD9_LEPOC Unreviewed; 4634 AA.
AC W5LXD9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Dynein axonemal heavy chain 5 {ECO:0000313|Ensembl:ENSLOCP00000000796.1};
GN Name=DNAH5 {ECO:0000313|Ensembl:ENSLOCP00000000796.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000000796.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000000796.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; AHAT01012339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01012340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSLOCT00000000800.1; ENSLOCP00000000796.1; ENSLOCG00000000680.1.
DR GeneTree; ENSGT00940000155533; -.
DR HOGENOM; CLU_000038_9_1_1; -.
DR Proteomes; UP000018468; Linkage group LG11.
DR Bgee; ENSLOCG00000000680; Expressed in ovary and 7 other cell types or tissues.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF13; DYNEIN CYTOPLASMIC 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1983..2119
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2262..2391
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2591..2789
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 893..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1074..1095
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3219..3253
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3439..3487
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3745..3824
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 894..928
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1074..1092
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4634 AA; 530248 MW; 212569FEDF35F669 CRC64;
MSRAFRKHLW KQSVTRVLKQ KLKEEREAKR AQLDGRHDYV LATVASCLGL ERGDIEDAIL
EGTQIDRMDR FFAAGGLPHI MFYYQDVEPA EAGSSGGLGV GFTLASSSVG KNKKPKVFLT
EGRDVALSGV CVFFTRANVS KAITSENVHR DVNFNMLDTT EVGLLKSVEQ LLSEIFIPTL
KKMNYGWGDL ASPQAASVRQ DFLSSLDSFV AVLIGAQESL MEKVNLKECE TYDLKTLKGP
SDFIAVANST EALEKIEACI KVWIKQIEQV LAESDQLRKE ADDLGPRAEL DHWKKRMSRF
NYLLDQLKSP DVKAVLGVLT VAKSKLLKTW RELDTRITDS ANEAKDNVKY LYTLEKFCDP
LYNSDPVSMV EAIPGLINAI RMIHSISRYY NTSEKITSLF VKVTNQMITA CKAYITQNGT
ATIWDQPQEI MAEKLKAAVR LNEEYQHCFH KTKQKLEESP SERQFDFSEM YIFGKFDTFQ
RRLNKILGMF DTIKTYSALQ DSKMESLETM STKFQGIVLT MKKKQYNFLD QRKTDFDQDY
VDFCKSTNDL HNQLKTFMDT SFEKIQNTQR ALIVLKKFER LGIPDLGIDD KYQRILQNYG
RDIEMASKIY TKQKNEPPIA RDLPPVSGRI MWARQLFHRI QEPMDLFQQH PSVLQTPEAK
RIIRNYNKVA KVLLEFEVLY HRGWLRQIET AKAGLQASLL VKSSETGELF VNFDPQILTL
IRETDCMSRM GLEIPPFAAA LQQKQDLLKK NCNKLQMVLT ENTRVRSKLP SAFRQLAASH
LAKVDEAIQP GLTSLNWSSL NIEKYLNGII SALAELELLL DRVNDLVEFR IDAVLQEMST
APLCKLPDDE PFTCEEFVQM TKELCIKGAQ RLQTKSSLVE EAANELINML LDFEPQNKER
EEKPNDESRD ESKIASESDE DDGKSENRLF SRNTNQGSTG PPSPLAKKKK KNIAEILEEE
AHELLSHFNH RNVEALLRVT RNSLETLRKR IHISSIIHFL EGDSSNKQKS TGQPIFRTNI
TLSIPNITMV PALDEVQQAL NRVVEYIVSV SKGVGQWSKE RISKHKMSER RIAALRRDSR
DSDSEEGDTL HRNGSTSDIS VSVNHTFCFQ SRNYYKTVSE NKEIVKLVSV LSTSINSTKK
EVMTALERFS CYHHIWQKER EETIQKFIMG SPLLSEFESQ ILYYRDLELE INAEPEFVTV
GALALYTDEL KLALTTETKA WMVDFGRHCN RKYRSEMDNI FTFVEEASKK LNRQIKDLDD
IRIAMTALKE IREHQIAIDF QVSPIEESYA MLNKYDLLVA KEEVEKVDTL RYTWEKLLVR
GTEVQNELVS LQPNFRGELI SNVQTFVEDC DHFYKEYEKD GPMVVGLAPQ DASDRLIMFQ
NRFDNLYRKY ITYTGGEELF GLPVTQHPQL LEIKKQLTLL QKLYGLYSNV IDTVNGYYDI
LWSDVNIEKI NNELLDFQTR CRKLPRALKE WQAFLDLKKT IDDFNECCPL LELMANKAMM
ARHWKRITEV TGHSFDVESD TFKLRNIMEA PLLKCKEEIE DICISAVKER DIEQKLKQVI
AEWDNKTFTF ANFKTRGELL LRGDSTSEII ANMEDSLMIL GSLMSNRYNT PFKAQIQKWV
QNLSNTTDII ENWMTVQNLW IYLEAVFVGG DIAKQLPKEA KRFSNIDKSW VKIMTRAHEM
PNVVQCCVGD ETMGQLLPHL LEQLEICQKS LTGYLEKKRL LFPRFFFVSD PALLEILGQA
SDSHTIQAHL LNVFDNIKTV RFHDKVYDRI LAICSREGET VELDRPVMAE GNVEIWLNAL
LKESQRSLHL VIKQAAVSIQ DSSFQLIEFL NYFPAQIGLL GIQMIWTRDS EEALTNARYD
RKIMTKTNQS FLELLNTLID MTTKDLSPVE RIKYETLITI HVHQRDIFDD LCRLHIKSPS
DFEWLKQCRF YFNEDSDKML INITDVGFIY QNEFLGCTDR LVITPLTDRC YITLAQALGM
SMGGAPAGPA GTGKTETTKD MGRCLGKYVV VFNCSDQMDF RGLGRIFKGL AQSGSWGCFD
EFNRIDLPVL SVAAQQIAIV LTCKKERKKN FVFTDGDNVE MNPEFGIFLT MNPGYAGRQE
LPENLKINFR SVAMMVPDRQ IIIRVKLASC GFIDNIELAR KFFTLYKLCE EQLSKQVHYD
FGLRNILSVL RTLGAAKRAN PNDTESTIVM RVLRDMNLSK LIDEDEPLFL SLIEDLFPGI
QLDKAGYPEL ETAIDRQVAE AGLISHPPWK LKVIQLFETQ RVRHGMMALG PSGAGKTACI
HTLMRAMTDC GQPHREMRMN PKAITAPQMF GRLDVATNDW TDGIFSTLWR KTLRAKKGEH
IWIVLDGPVD AIWIENLNSV LDDNKTLTLA NGDRIPMAAN CKIVFEPHNI DNASPATVSR
NGMVFMSSSV LNWSPILEGW LKKRSLQEGN VLRELYSSSF LELFRFSVQS LEYKMEMLEA
FVIMQSISML QGLIPPKEQG GEVTREHLGR LYVFALMWSV GALLELEGRR KLETWLRGHK
NIRLDLPSIP AGSEDTMFDY HVTSEGQWVH WNMRVEEYIY PPDSTPEYGS ILVPNVDNVR
TDFLIQTIAK QGKAVLLIGE QGTAKTVIIK GYMSKYDPES HMAKSLNFSS ATTPLMFQRT
IESYVDKRMG TTYGPPAGKK MSIFIDDINM PVINEWGDQV TNEIVRQVME QNGFYNLEKP
GEFTNIVDIQ FLAAMIHPGG GRNDIPQRLK RQFSIFNCTL PSNSSIDKIF GVIGVGHYCS
HRGFSEVVRG TVAKLVSLTR KLWQMTKIKM LPTPAKFHYI FNLRDLSRIW QGMLNTTSEV
VSSQDVVLRL WKHECKRVIA DRFTVTEDVA WFDRALSKLM EEELGEEDKA VVDPAVDAYF
VDFLRDAPEA TGEEPEDADF EMPKVYEPIE SFESLKDRLN IFLAQYNENI RGAGMDMVFF
RDAMIHLVKV SRIIRTPRGN ALLVGVGGSG KQSLTRLASF IAGYRTFQIT LTRSYNTSNL
MEDLKVLYRT AGQQGKGISF IFTDNEIKDE SFLEYMNNVL SSGEVSNLFA RDEIDEITGD
LIPIMKKEFP RRPPSNENLY EYFMSRVRQN LHVVLCFSPV GEKFRNRALK FPALISGCTM
DWFSRWPKDA LIAVSEHFLS TYDIDCTAQV KGEVVQCMGS FQDGVAEKCV EYFQRYRRST
HVTPKSYLSF IQGYKTIYKE KHSEVQTLAN RMNTGLQKLK EASESVAALS KELEVKEKEL
QVANEKADMV LKEVTVKAQA AEKVKVEVQK VKDKAQAIVD SIFADKAIAE EKLEAAKPAL
QEAEAALLTI KPSDIATVRT LGRPPHLIMR IMDCVLLLFQ RRVNTVKIDP EKNCIIPSWQ
ESLKLMTAGN FLGSLQTFPK DTINEEVVEL LHPYFDLADY NIETAKRVCG NVAGLCSWTE
AMAAFFSINK EVLPLKANLA VQENRLAIAN ADLQNAQAEL DAKQAELDVV QAEYEQAMME
KQTLLEDADR CRHKMQTASS LISGLAGEKA RWTEQSKEFA AQTKRLVGDV LLATAFLSYS
GPFNQEFRNL LLTDWQKEMK TRRIPFGNNL NLTEMLIDAP TVSEWNLQGL PNDDLSIQNG
IIVTKAARFP LLIDPQTQGK IWIKNKEAKN ELQITSLNHK YFRNHLEDSL SLGRPMLIED
VGEELDPALD NVLEKNFIKT GSTYKVKVGD KEVDVMSGFR LYVTTKLPNP AYTPEISART
SIIDFTVTMK GLEDQLLGRV ILTEKQELEK ERTDLMEDVT SNKRKMKELE DNLLFRLTST
QGSLVDDESL IIVLSNTKRT AEEVTQKLQT AAETEIQINA AREEYRPVAT RGSILYFLIT
EMSMVNVMYQ TSLRQFLGLF DLSLASRSSK SPITSKRIAN IIEYMTFEVH NYAARGLYEE
HKFLFTLLLT LKIDMQSNRV KHEEFLTLIK GGASLDLKAC PAKAAKWILD MTWLNLVELS
KLWQFSDILD QISRNEKQWK NWFDKEAPEE ESIPNAYDQA LDCFRRLLLI RSWCPDRTIA
QARKYIMDSM GQKYAEGVIL DLENTWEESG PRIPLICFLS MGSDPTDSII ALGKRLKIET
RYVSMGQGQG VHARKLLQQT MTNGGWALLQ NCHLGLDFLD ELMDTITETE TMHETFRLWM
TTEVHKQFPI TLLQMSIKFT NEPPQGLKAG LKRTYGGINQ DLLDVSNMTQ WKPMLYAVAF
LHSTVQERRK FGPLGWNIPY EFNQADFNAT VQFIQNHLDD MDIKKGVSWN TVRYMIGEIQ
YGGRVTDDYD KRLLNTFAKV WFSENMFGAD FFFYKGYSIP KCVNVDQYLQ YIQGLPVYDT
PEVFGLHPNA DITYQSKLAK DVLDTILSIQ PKDSSSGGGE TREAIVGRLA DDMLEKLPPD
YVPFEVRERL QKMGPLQPMN IFLRQEIDRM QRIIVLVRNT LTDLKLAIDG TIIMSENLRD
ALDCMYDARI PSRWKKASWA SSTLGFWFTE LLERNRQFQS WIFEGRPNCF WMTGFFNPQG
FLTAMRQEIT RANKGWALDR MVLCNEVTKW MKDDITQPPT EGVYVYGLYL EGAGWDRRNC
KLIESKPKAL FEMMPVIRIY AENNGLKDPR LYTCPIYKKP VRTDLNYIAA VELRTVQPPE
HWILRGVALL CDVK
//
