ID W5LY49_LEPOC Unreviewed; 737 AA.
AC W5LY49;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Myosin heavy chain 6 {ECO:0000313|Ensembl:ENSLOCP00000001056.1};
GN Name=MYH6 {ECO:0000313|Ensembl:ENSLOCP00000001056.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000001056.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000001056.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 7918.ENSLOCP00000001056; -.
DR Ensembl; ENSLOCT00000001060.1; ENSLOCP00000001056.1; ENSLOCG00000000930.1.
DR eggNOG; KOG0161; Eukaryota.
DR GeneTree; ENSGT00940000154805; -.
DR HOGENOM; CLU_000192_7_5_1; -.
DR InParanoid; W5LY49; -.
DR OMA; ILERXAS; -.
DR Proteomes; UP000018468; Unassembled WGS sequence.
DR Bgee; ENSLOCG00000000930; Expressed in larva and 6 other cell types or tissues.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF706; MYOSIN-11; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 19..684
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 561..583
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 112..119
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 737 AA; 83905 MW; 83C796BF04475086 CRC64;
QTVTVKECDV HPQNPPKFDK IEDMAMFTFL HEPAVLFNLK ERYAAWMIYT YSGLFCVTVN
PYKWLPVYDS AVVAAYRGKK RTEAPPHIFS ISDNAYQYML ADRENQSILI TGESGAGKTV
NTKRVIQYFA SIAAVGGKKD SAAANKGTLE DQIIQANPAL EAFGNAKTVR NDNSSRFGKF
IRIHFGASGK LASADIETYL LEKSRVTFQL KSERDYHIFY QILSQKKPEL LEMLLITNNP
YDYTYISQGE TTVASIDDAE ELMATDSAFD VLGFTQEEKN GIYKLTGAIM HYGNMKFKQK
QREEQAESDG TEDADKSAYL MGLNSADLIK GLCHPRVKVG NEWVTKGQNV QQVYYSIGAL
SKAVYEKMFL WMVVRINQSL DTKQPRQYFI GVLDIAGFEI FDFNTFEQMC INFTNEKLQQ
FFNHHMFVLE QEEYKKEGIE WEFIDFGMDL QACIDLIEKP MGIMSILEEE CMFPKASDAT
FKAKLYDNHL GKSNNFXKNK DPLNETVVGL YQKSSVKLLS NLFSNYAGAD SGPTQESKGK
GGGKKKGSSF QTVSALHREN LNKLMTNLRS THPHFVRCLI PNETKTPGAM ENSLVMHQLR
CNGVLEGIRI CRKGFPNRIL YGDFKQRYRI LNPSAIPEGQ FIDSKKGAEK LLGSLDIDHQ
QYKFGHTKVF FKAGLLGQLE EMRDDRLSLI ITAIQARSRG LLSRIEYQKI VERRDSLLVI
QWNVRAFMGV KNWPWMK
//
