ID W5LY81_LEPOC Unreviewed; 624 AA.
AC W5LY81;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Glycerophosphodiester phosphodiesterase domain containing 5b {ECO:0000313|Ensembl:ENSLOCP00000001088.1};
GN Name=GDPD5 {ECO:0000313|Ensembl:ENSLOCP00000001088.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000001088.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000001088.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycerophosphoryl diester phosphodiesterase
CC family. {ECO:0000256|ARBA:ARBA00007277}.
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DR EMBL; AHAT01003359; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01003360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5LY81; -.
DR STRING; 7918.ENSLOCP00000001088; -.
DR Ensembl; ENSLOCT00000001092.1; ENSLOCP00000001088.1; ENSLOCG00000000967.1.
DR eggNOG; KOG2258; Eukaryota.
DR GeneTree; ENSGT00940000159690; -.
DR HOGENOM; CLU_024259_1_0_1; -.
DR InParanoid; W5LY81; -.
DR OMA; CKHCRYR; -.
DR Proteomes; UP000018468; Linkage group LG3.
DR Bgee; ENSLOCG00000000967; Expressed in camera-type eye and 13 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0008889; F:glycerophosphodiester phosphodiesterase activity; IBA:GO_Central.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IBA:GO_Central.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR InterPro; IPR030395; GP_PDE_dom.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR PANTHER; PTHR23344:SF6; GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR23344; GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE; 1.
DR Pfam; PF03009; GDPD; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS51704; GP_PDE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 249..507
FT /note="GP-PDE"
FT /evidence="ECO:0000259|PROSITE:PS51704"
SQ SEQUENCE 624 AA; 71162 MW; DA3FAFC75A79C698 CRC64;
MNGVVGFPVP HGLLVGSDGR SMVKHQPLQV YERQLCLSCL TGIYGCRWKR YQRSHDDTTK
WERMWFLILS CTFFLLLVWF YFWWEAHNDY NEFNWFLYNR SGDWSDGSVP ILTATAAGFT
YIVFLMVLAL CHVAVGQQLN LHWLHKIGVT AVLVTTVIAV MSVEQLWREE WDIVLISLQA
KGPFLHIGAL AVMTVLAWLV AGQFARSEKT GFQAVLLLVY ACALLALYLV PLAITSPCLM
ERSSLSPRPE VIGRRGAPML APENTLMSFR KALQQKVRGW EVDVTISLDG VPFLMRDRTL
RRTTNVEWVF PERQFEDAAM FNWTDLQALN AGQWFLKDDP FWTAHQLSQK DLAQADNQSV
CSLRELLQLA ARNNRSVLLT LRRPPEEHPF HDGWINATLD TVLQSGIQQE LVMWTPHTDR
QLVRRMAPGL QQTSAVKASV EALRQEGIVK LSLRYNQASP REIRAFSASN ISLNLFTVNE
PWLFSVLWCS GVPSVSSDAP HILKKVPYPI WLMTPDEYCL VWITSDLVSF SLIIGIFVLQ
NYHMIRWRLG SIRSYNPEQI MLSAAVRRSS RDVNIMKEKL IFSEINNGVG SAEELSLCGD
HGYDGYANEA ITPFDQPSLK MHVH
//
