ID W5LZ71_LEPOC Unreviewed; 176 AA.
AC W5LZ71;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Alpha-crystallin A chain {ECO:0000256|ARBA:ARBA00018827};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000001428.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000001428.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC {ECO:0000256|PIRNR:PIRNR036514, ECO:0000256|PROSITE-ProRule:PRU00285,
CC ECO:0000256|RuleBase:RU003616}.
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DR EMBL; AHAT01025129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006638940.1; XM_006638877.2.
DR AlphaFoldDB; W5LZ71; -.
DR STRING; 7918.ENSLOCP00000001428; -.
DR Ensembl; ENSLOCT00000001433.1; ENSLOCP00000001428.1; ENSLOCG00000001257.1.
DR GeneID; 102691439; -.
DR KEGG; loc:102691439; -.
DR CTD; 1409; -.
DR eggNOG; KOG3591; Eukaryota.
DR GeneTree; ENSGT00940000160159; -.
DR HOGENOM; CLU_095001_2_0_1; -.
DR InParanoid; W5LZ71; -.
DR OMA; QQDDHGY; -.
DR OrthoDB; 3014506at2759; -.
DR Proteomes; UP000018468; Linkage group LG17.
DR Bgee; ENSLOCG00000001257; Expressed in camera-type eye and 5 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR GO; GO:0009408; P:response to heat; IBA:GO_Central.
DR CDD; cd06497; ACD_alphaA-crystallin_HspB4; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR InterPro; IPR003090; Alpha-crystallin_N.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR PANTHER; PTHR45640:SF14; ALPHA-CRYSTALLIN A CHAIN; 1.
DR PANTHER; PTHR45640; HEAT SHOCK PROTEIN HSP-12.2-RELATED; 1.
DR Pfam; PF00525; Crystallin; 1.
DR Pfam; PF00011; HSP20; 1.
DR PIRSF; PIRSF036514; Sm_HSP_B1; 1.
DR PRINTS; PR00299; ACRYSTALLIN.
DR SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR PROSITE; PS01031; SHSP; 1.
PE 3: Inferred from homology;
KW Eye lens protein {ECO:0000256|ARBA:ARBA00022613};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR036514-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR036514-1}.
FT DOMAIN 55..167
FT /note="SHSP"
FT /evidence="ECO:0000259|PROSITE:PS01031"
FT REGION 151..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 103
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR036514-1"
FT BINDING 105
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR036514-1"
FT BINDING 110
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR036514-1"
SQ SEQUENCE 176 AA; 20090 MW; FAE3B80467BAC9E7 CRC64;
MDIAIQHPWF RRALASLNPS RLFDQFFGDG LFEYDLFPYA ASTISPYYRQ SLFRNFMESA
NSGMSEVRSD RDKFTIYLDV KHFSPDDLNV KIIDDYVEIQ GKHGERQDDH GYISREFHRR
YRLPSNMDQS GITCSLSADG ILTFCGPKIS SGADSSRGDR NIPVTREEKP TSAAPS
//
