ID W5M0K6_LEPOC Unreviewed; 507 AA.
AC W5M0K6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Solute carrier family 19 member 2 {ECO:0000313|Ensembl:ENSLOCP00000001913.1};
GN Name=SLC19A2 {ECO:0000313|Ensembl:ENSLOCP00000001913.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000001913.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000001913.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|PIRNR:PIRNR028739}; Multi-
CC pass membrane protein {ECO:0000256|PIRNR:PIRNR028739}.
CC -!- SIMILARITY: Belongs to the reduced folate carrier (RFC) transporter (TC
CC 2.A.48) family. {ECO:0000256|ARBA:ARBA00005773,
CC ECO:0000256|PIRNR:PIRNR028739}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AHAT01025101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015219020.1; XM_015363534.1.
DR AlphaFoldDB; W5M0K6; -.
DR Ensembl; ENSLOCT00000001918.1; ENSLOCP00000001913.1; ENSLOCG00000001660.1.
DR GeneID; 102684955; -.
DR KEGG; loc:102684955; -.
DR CTD; 10560; -.
DR eggNOG; KOG3810; Eukaryota.
DR GeneTree; ENSGT00950000183022; -.
DR HOGENOM; CLU_036909_0_1_1; -.
DR InParanoid; W5M0K6; -.
DR OMA; CYRCRPL; -.
DR OrthoDB; 51626at2759; -.
DR Proteomes; UP000018468; Linkage group LG17.
DR Bgee; ENSLOCG00000001660; Expressed in pharyngeal gill and 13 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002666; Folate_carrier.
DR InterPro; IPR036259; MFS_trans_sf.
DR NCBIfam; TIGR00806; rfc; 1.
DR PANTHER; PTHR10686; FOLATE TRANSPORTER; 1.
DR PANTHER; PTHR10686:SF19; THIAMINE TRANSPORTER 1; 1.
DR Pfam; PF01770; Folate_carrier; 1.
DR PIRSF; PIRSF028739; Folate_carrier; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|PIRNR:PIRNR028739, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|PIRNR:PIRNR028739}.
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 219..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 507 AA; 56801 MW; 6230C70849E864FD CRC64;
MSETWLYPTI LLCFYGFFSS LRPSEPFLTA FLMGPDKNLT EKEVVNKIYP VWTYSYLVLL
FPVFLATDYL RYKAVIILQG ASFIVTYVML VQAQGVLCMQ ILEFFYGLAT AAEIAYYSYI
YSVVESARYQ QVTGYCRSIT LVGSAVGSLT GQVLVSTAQI RLLYLNIVTL VCMIVAFLAP
WFLPVASRSL FFHQLPGRPG KEARVEQAPA VPLGELYRTE QEDPESKEPL NPKSCPLPDG
EAEASRAGGK SVSEVLRTVW RDFLQCYSSQ TLLCWSVWWA LSTCGYYQVI NYAQALWERV
LPSQDFEIYN GYVETISTLL GAAAAFGVGY VKIPWAAWGE LALCSFSVVI AVAVYLMDTV
RNVWVCYTSY IVFRATYMLL ITIATYQIAV NLSMERYALV FGVNTFIALA LQTVLTVIVV
DSSGLGLDIF AQFLIYASYF AVIAVIFLLA GIYRKLVRCR RRPQCQAESA ETESDCARDT
ETGEDVIKHL SVHGVQSTET GYVSEKH
//
